Avizafone  (Synonyms: Pro-diazepam)

Avizafone (Pro-diazepam), a pro-drug of Diazepam, is an anticonvulsant agent. Avizafone can be used as an antidote of nerve agent poisoning. In vivo, Avizafone is rapidly hydrolyzed by aminopeptidase to produce lysine and diazepam. Avizafone has research areas including neurological disease, such as epilepsy^[1][2][3].

Avizafone (3.5 mg/kg; i.m.; single dose) prevents seizures, reduces clinical signs, eliminates 24-hour mortality, and mitigates brain lesions in Charles River guinea pigs (soman poisoned) (with a 24-hour mortality rate of 0%)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

430.93

C₂₂H₂₇ClN₄O₃

65617-86-9

O=C(CNC([C@H](CCCCN)N)=O)N(C1=CC=C(C=C1C(C2=CC=CC=C2)=O)Cl)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Clair P, et al. Stability study of a new antidote drug combination (Atropine-HI-6-Prodiazepam) for treatment of organophosphate poisoning. Eur J Pharm Sci. 2000 Jan;9(3):259-63.  [Content Brief]

  [2]. Lallement G, et al. Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics. Arch Toxicol. 2000 Oct;74(8):480-6.  [Content Brief]

  [3]. Taysse L, et al. Protection against soman-induced neuropathology and respiratory failure: a comparison of the efficacy of diazepam and avizafone in guinea pig. Toxicology. 2006;225(1):25-35.  [Content Brief]