65617-86-9
Chemical Structure
Avizafone
Synonym(s): Pro-diazepam
- CAS No.: 65617-86-9
- Formula:C22H27ClN4O3
- Molecular Weight:430.93
IUPAC Name: (S)-2,6-diamino-N-(2-((2-benzoyl-4-chlorophenyl)(methyl)amino)-2-oxoethyl)hexanamide
InChIKey: LTKOVYBBGBGKTA-SFHVURJKSA-N
SMILES: O=C(CNC([C@H](CCCCN)N)=O)N(C1=CC=C(C=C1C(C2=CC=CC=C2)=O)Cl)C
Biological Activity: Avizafone (Pro-diazepam), a pro-drug of Diazepam, is an anticonvulsant agent. Avizafone can be used as an antidote of nerve agent poisoning. In vivo, Avizafone is rapidly hydrolyzed by aminopeptidase to produce lysine and diazepam. Avizafone has research areas including neurological disease, such as epilepsy[1][2][3].
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Avizafone | Avizafone (Pro-diazepam), a pro-drug of Diazepam, is an anticonvulsant agent. Avizafone can be used as an antidote of nerve agent poisoning. In vivo, Avizafone is rapidly hydrolyzed by aminopeptidase to produce lysine and diazepam. Avizafone has research areas including neurological disease, such as epilepsy. | |||||||||||||||||||||
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Avizafone-d5 dihydrobromide | Avizafone-d5 dihydrobromide is the deuterium labeled Avizafone dihydrobromide. Avizafone (Pro-diazepam) dihydrobromide, a pro-drug of Diazepam, is an anticonvulsant agent. Avizafone dihydrobromide can be used as an antidote of nerve agent poisoning. In vivo, Avizafone is rapidly hydrolyzed by aminopeptidase to produce lysine and diazepam. Avizafone dihydrobromide has research areas including neurological disease, such as epilepsy. | |||||||||||||||||||||
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- [1]. Clair P, et al. Stability study of a new antidote drug combination (Atropine-HI-6-Prodiazepam) for treatment of organophosphate poisoning. Eur J Pharm Sci. 2000 Jan;9(3):259-63. [Content Brief]
- [2]. Lallement G, et al. Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics. Arch Toxicol. 2000 Oct;74(8):480-6. [Content Brief]
- [3]. Taysse L, et al. Protection against soman-induced neuropathology and respiratory failure: a comparison of the efficacy of diazepam and avizafone in guinea pig. Toxicology. 2006;225(1):25-35. [Content Brief]
Keywords
