2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. Bisphenol F bis(2-chloro-1-propanol) ether

Bisphenol F bis(2-chloro-1-propanol) ether  (Synonyms: BFDGE·2HCl)

Cat. No.: HY-W585917
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Bisphenol F bis(2-chloro-1-propanol) ether (BFDGE·2HCl) is an androgen receptor antagonist with a human IC50 of 18 μM. Bisphenol F bis(2-chloro-1-propanol) ether binds to the androgen receptor. Bisphenol F bis(2-chloro-1-propanol) ether (BFDGE·2HCl) can be used for research on hormonal activity.

For research use only. We do not sell to patients.

Bisphenol F bis(2-chloro-1-propanol) ether

Bisphenol F bis(2-chloro-1-propanol) ether Chemical Structure

CAS No. : 374772-79-9

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Bisphenol F bis(2-chloro-1-propanol) ether Related Antibodies

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Description

Bisphenol F bis(2-chloro-1-propanol) ether (BFDGE·2HCl) is an androgen receptor antagonist with a human IC50 of 18 μM. Bisphenol F bis(2-chloro-1-propanol) ether binds to the androgen receptor. Bisphenol F bis(2-chloro-1-propanol) ether (BFDGE·2HCl) can be used for research on hormonal activity[1][2].

In Vitro

Bisphenol F bis(2-chloro-1-propanol) ether (10 pM-10 μM M; 16-24 h) exhibits no androgen agonistic activity in AR-EcoScreen CHO-K1 cells[1].
Bisphenol F bis(2-chloro-1-propanol) ether (1 nM-100 μM; 16-24 h) acts as a potent androgen antagonist in AR-EcoScreen CHO-K1 cells, with an IC50 of 5.2×10-6 M for inhibiting DHT-induced luciferase activity, and shows no cell toxicity at active concentrations[1].
Bisphenol F bis(2-chloro-1-propanol) ether binds to human androgen receptor with an IC50 of 1.8×10-5 M, reducing specific testosterone binding in a concentration-dependent manner[1].
Bisphenol F bis(2-chloro-1-propanol) ether has negligible binding affinity for human estrogen receptor α, with less than 40% inhibition of specific 17β-estradiol binding at concentrations up to 1.9×10-4 M[1].
Bisphenol F bis(2-chloro-1-propanol) ether (100 nM-100 μM; 24 h) exhibits no estrogenic agonistic activity in MVLN cells when tested at concentrations[1].
Bisphenol F bis(2-chloro-1-propanol) ether (100 nM-100 μM) does not induce proliferation of estrogen-sensitive MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bisphenol F bis(2-chloro-1-propanol) ether Related Antibodies
Molecular Weight

385.28

Formula

C19H22Cl2O4
CAS No.
SMILES

ClC(COC1=CC=C(CC2=CC=C(C=C2)OCC(CO)Cl)C=C1)CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Bisphenol F bis(2-chloro-1-propanol) ether Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bisphenol F bis(2-chloro-1-propanol) ether374772-79-9BFDGE·2HClAndrogen Receptorandrogen receptortestosteronehuman androgen receptorDHThuman estrogen receptor αAR-EcoScreen CHO-K1 cellsMCF-7 cells17β-estradiolMVLN cellsluciferase activityInhibitorinhibitorinhibit

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