Bisphenol F bis(2-chloro-1-propanol) ether
Bisphenol F bis(2-chloro-1-propanol) ether (BFDGE·2HCl) is an androgen receptor antagonist with a human IC50 of 18 μM. Bisphenol F bis(2-chloro-1-propanol) ether binds to the androgen receptor. Bisphenol F bis(2-chloro-1-propanol) ether (BFDGE·2HCl) can be used for research on hormonal activity.
For research use only. We do not sell to patients.
- CAS No.: 374772-79-9
- Formula: C19H22Cl2O4
- Molecular Weight:385.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Bisphenol F bis(2-chloro-1-propanol) ether (10 pM-10 μM M; 16-24 h) exhibits no androgen agonistic activity in AR-EcoScreen CHO-K1 cells[1].
Bisphenol F bis(2-chloro-1-propanol) ether (1 nM-100 μM; 16-24 h) acts as a potent androgen antagonist in AR-EcoScreen CHO-K1 cells, with an IC50 of 5.2×10-6 M for inhibiting DHT-induced luciferase activity, and shows no cell toxicity at active concentrations[1].
Bisphenol F bis(2-chloro-1-propanol) ether binds to human androgen receptor with an IC50 of 1.8×10-5 M, reducing specific testosterone binding in a concentration-dependent manner[1].
Bisphenol F bis(2-chloro-1-propanol) ether has negligible binding affinity for human estrogen receptor α, with less than 40% inhibition of specific 17β-estradiol binding at concentrations up to 1.9×10-4 M[1].
Bisphenol F bis(2-chloro-1-propanol) ether (100 nM-100 μM; 24 h) exhibits no estrogenic agonistic activity in MVLN cells when tested at concentrations[1].
Bisphenol F bis(2-chloro-1-propanol) ether (100 nM-100 μM) does not induce proliferation of estrogen-sensitive MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 374772-79-9
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Molecular Weight 385.28
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Formula C19H22Cl2O4
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SMILES
ClC(COC1=CC=C(CC2=CC=C(C=C2)OCC(CO)Cl)C=C1)CO
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Synonyms
BFDGE·2HCl
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bisphenol F bis(2-chloro-1-propanol) ether Related Classifications
HY-W585917 Related Classifications
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