2. Apoptosis
  3. Apoptosis
  4. BMS 310705

BMS 310705  (Synonyms: 21-Aminoepothilone B)

Cat. No.: HY-107020 Pureza: 99.59%
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BMS 310705 (21-Aminoepothilone B) is an analog of Epothilone B (HY-17029), targeting to malignancies such as ovarian, renal, bladder, and lung carcinoma. BMS 310705 induces significant apoptosis via mitochondrial-mediated pathway.

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BMS 310705

BMS 310705 Estructura química

No. CAS : 280578-49-6

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BMS 310705 Related Antibodies

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Descripciòn

BMS 310705 (21-Aminoepothilone B) is an analog of Epothilone B (HY-17029), targeting to malignancies such as ovarian, renal, bladder, and lung carcinoma. BMS 310705 induces significant apoptosis via mitochondrial-mediated pathway[1].

In Vitro

BMS 310705 (0.01-0.5 μM; 1 h) induces cell apoptosis in OC-2 cells[1].
BMS 310705 (0.5 μM; 1 h) increases the activity of caspase-9 and -3, and leads to cytochrome c release[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS 310705 Related Antibodies

Apoptosis Analysis[1]

Cell Line: OC-2 cells
Concentration: 0.01 μM, 0.025 μM, 0.05 μM, and 0.5 μM
Incubation Time: 1 hour; reincubation in drug-free media at 24-, 48-, 72-, and 96-h intervals
Result: Induced maximal cell apoptosis at 0.05 μM, and exhibited time-dependent manner.
Peso molecular

522.70

Fòrmula

C27H42N2O6S
No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

C[C@@]12[C@H](C[C@H](OC(C[C@@H](C(C)(C)C([C@H](C)[C@@H](O)[C@@H](C)CCC2)=O)O)=O)/C(C)=C/C3=CSC(CN)=N3)O1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (191.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9131 mL 9.5657 mL 19.1314 mL
5 mM 0.3826 mL 1.9131 mL 3.8263 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.78 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación

Purity: 99.59%

SDS (251 KB)

COA (259 KB) HNMR (440 KB) RP-HPLC (264 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9131 mL 9.5657 mL 19.1314 mL 47.8286 mL
5 mM 0.3826 mL 1.9131 mL 3.8263 mL 9.5657 mL
10 mM 0.1913 mL 0.9566 mL 1.9131 mL 4.7829 mL
15 mM 0.1275 mL 0.6377 mL 1.2754 mL 3.1886 mL
20 mM 0.0957 mL 0.4783 mL 0.9566 mL 2.3914 mL
25 mM 0.0765 mL 0.3826 mL 0.7653 mL 1.9131 mL
30 mM 0.0638 mL 0.3189 mL 0.6377 mL 1.5943 mL
40 mM 0.0478 mL 0.2391 mL 0.4783 mL 1.1957 mL
50 mM 0.0383 mL 0.1913 mL 0.3826 mL 0.9566 mL
60 mM 0.0319 mL 0.1594 mL 0.3189 mL 0.7971 mL
80 mM 0.0239 mL 0.1196 mL 0.2391 mL 0.5979 mL
100 mM 0.0191 mL 0.0957 mL 0.1913 mL 0.4783 mL
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BMS 310705 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS 310705280578-49-621-Aminoepothilone BBMS310705BMS-310705ApoptosisInhibitorinhibitorinhibit

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