BOC-(1R,3S)-3-aminocyclopentane carboxylic acid (Synonyms: (1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid)

Cat. No.: HY-W004812 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

BOC-(1R,3S)-3-aminocyclopentane carboxylic acid ((1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid) is a conformationally constrained peptide building block and a key component of SARS-CoV-2 main protease (Mpro) inhibitors. When incorporated into macrocyclic peptides, BOC-(1R,3S)-3-aminocyclopentane carboxylic acid not only helps generate high-affinity Mpro inhibitors by preorganizing the secondary structure of peptides, but also exerts sequence-dependent functional inhibition on the hydrolytic activity of Mpro. BOC-(1R,3S)-3-aminocyclopentane carboxylic is widely used in COVID-19-related research.

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BOC-(1R,3S)-3-aminocyclopentane carboxylic acid 화학구조

CAS No. : 161660-94-2

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	견적 받기
10 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

BOC-(1R,3S)-3-aminocyclopentane carboxylic acid significantly enhances the ability of macrocyclic peptides to resist peptidase-mediated degradation in human serum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

229.28

화학식

C₁₁H₁₉NO₄

CAS No.

161660-94-2

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H]1CC[C@H](NC(OC(C)(C)C)=O)C1)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : 100 mg/mL (436.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3615 mL	21.8074 mL	43.6148 mL
5 mM	0.8723 mL	4.3615 mL	8.7230 mL
10 mM	0.4361 mL	2.1807 mL	4.3615 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.0%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (246 KB) HNMR (116 KB)

Handling Instructions (2659 KB)

References

[1]. Miura T, et al. In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2, 4-amino acids targeting the SARS-CoV-2 main protease[J]. Nature Chemistry, 2023, 15(7): 998-1005.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.3615 mL	21.8074 mL	43.6148 mL	109.0370 mL
	5 mM	0.8723 mL	4.3615 mL	8.7230 mL	21.8074 mL
	10 mM	0.4361 mL	2.1807 mL	4.3615 mL	10.9037 mL
	15 mM	0.2908 mL	1.4538 mL	2.9077 mL	7.2691 mL
	20 mM	0.2181 mL	1.0904 mL	2.1807 mL	5.4518 mL
	25 mM	0.1745 mL	0.8723 mL	1.7446 mL	4.3615 mL
	30 mM	0.1454 mL	0.7269 mL	1.4538 mL	3.6346 mL
	40 mM	0.1090 mL	0.5452 mL	1.0904 mL	2.7259 mL
	50 mM	0.0872 mL	0.4361 mL	0.8723 mL	2.1807 mL
	60 mM	0.0727 mL	0.3635 mL	0.7269 mL	1.8173 mL
	80 mM	0.0545 mL	0.2726 mL	0.5452 mL	1.3630 mL
	100 mM	0.0436 mL	0.2181 mL	0.4361 mL	1.0904 mL

BOC-(1R,3S)-3-aminocyclopentane carboxylic acid Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BOC-(1R,3S)-3-aminocyclopentane carboxylic acid161660-94-2(1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acidDrug IntermediateSARS-CoVDrug IintermediateSARS coronavirusmacrocyclic peptide librariescoronavirus disease 2019peptide secondary structureshuman serumbacterial autoinducer synthase CepImacrocyclic peptidesSARS-CoV-2 main proteaseMprocovid-19Inhibitorinhibitorinhibit

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BOC-(1R,3S)-3-aminocyclopentane carboxylic acid (Synonyms: (1S,3S)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid)

BOC-(1R,3S)-3-aminocyclopentane carboxylic acid Related Antibodies

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

BOC-(1R,3S)-3-aminocyclopentane carboxylic acid Related Antibodies

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