2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Boc-Val-Cit-PAB

Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Boc-Val-Cit-PAB

Boc-Val-Cit-PAB 構造式

CAS 番号 : 870487-09-5

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
100 mg $110 在庫あり
250 mg $195 在庫あり
1 g $480 在庫あり
5 g $1440 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

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Boc-Val-Cit-PAB 関連抗体

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ADC Linker アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Protease Cleavable Linker

 

Cleavable Linker

 

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-Val-Cit-PAB 関連抗体
分子量

479.57

分子式

C23H37N5O6
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OC(C)(C)C)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (208.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0852 mL 10.4260 mL 20.8520 mL
5 mM 0.4170 mL 2.0852 mL 4.1704 mL
10 mM 0.2085 mL 1.0426 mL 2.0852 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.86%

COA (248 KB) HNMR (283 KB) LCMS (94 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0852 mL 10.4260 mL 20.8520 mL 52.1300 mL
5 mM 0.4170 mL 2.0852 mL 4.1704 mL 10.4260 mL
10 mM 0.2085 mL 1.0426 mL 2.0852 mL 5.2130 mL
15 mM 0.1390 mL 0.6951 mL 1.3901 mL 3.4753 mL
20 mM 0.1043 mL 0.5213 mL 1.0426 mL 2.6065 mL
25 mM 0.0834 mL 0.4170 mL 0.8341 mL 2.0852 mL
30 mM 0.0695 mL 0.3475 mL 0.6951 mL 1.7377 mL
40 mM 0.0521 mL 0.2607 mL 0.5213 mL 1.3033 mL
50 mM 0.0417 mL 0.2085 mL 0.4170 mL 1.0426 mL
60 mM 0.0348 mL 0.1738 mL 0.3475 mL 0.8688 mL
80 mM 0.0261 mL 0.1303 mL 0.2607 mL 0.6516 mL
100 mM 0.0209 mL 0.1043 mL 0.2085 mL 0.5213 mL
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Boc-Val-Cit-PAB Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-Val-Cit-PAB870487-09-5ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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製品名:
Boc-Val-Cit-PAB
製品番号:
HY-141141
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