2. Membrane Transporter/Ion Channel
  3. NKCC
  4. Bumetanide sodium

Bumetanide sodium  (Synonyms: Ro 10-6338 sodium; PF 1593 sodium)

Art. -Nr.: HY-17468A
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Bumetanide sodium, a highly potent loop diuretic, is a Na+-K+-Cl+ cotransporter (NKCC) blocker. Bumetanide sodium is a selective NKCC1 inhibitor, and also inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

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CAS. Nr. : 28434-74-4

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Bumetanide sodium Related Antibodies

Top Publications Citing Use of Products

    Bumetanide sodium purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Mar;44(5):1540-1562.  [Abstract]

    NKCC1-mediated Cl- influx was inhibited by furosemide, Bumetanide, and torsemide applied externally to the cells at 100 μM concentration.

    Bumetanide sodium purchased from MedChemExpress. Usage Cited in: J Physiol. 2025 May;603(9):2619-2632.  [Abstract]

    Representative short-circuit current traces (left) and summary graphs (right) from epithelia kept in control conditions, treated with IL-4 or treated with IL-17A/TNF-α. During recordings, CFTRinh-172 (apical, 10 µM) and Bumetanide (basolateral, 100 µM) were added sequentially after stimulation of CFTR with CPT-cAMP. Dotted and dashed lines indicate the baseline for cAMP-activated current and zero current level, as in previous legends. The graphs report the fraction of the cAMP-activated current blocked by CFTRinh-172 (I-172), bumetanide alone (bum) or both compounds together (tot).

    Bumetanide sodium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2022 Jun 21;19(1):163.  [Abstract]

    Representative images of immunofluorescence staining for p-NKCC1 and p-NKCC1-positive cell statistics of the choroid plexus at 3 days following Bumetanide treatment (6 rats/group, Welch's two-tailed unpaired t-test). Bar = 50 μm.

    Bumetanide sodium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2022 Jun 21;19(1):163.  [Abstract]

    Western blot analysis of p-NKCC1 and NLRP3 in the choroid plexus at 3 days after Bumetanide treatment.

    Bumetanide sodium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2022 Jun 21;19(1):163.  [Abstract]

    CSF secretion rates after Bumetanide treatment (6-8 rats/group, Welch's two-tailed unpaired t-test).

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    Beschreibung

    Bumetanide sodium, a highly potent loop diuretic, is a Na+-K+-Cl+ cotransporter (NKCC) blocker. Bumetanide sodium is a selective NKCC1 inhibitor, and also inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1][2].

    In Vitro

    Bumetanide sodium has inhibitory effects for the two major human splice variants of NKCCs, hNKCC1A and hNKCC2A [1].
    Bumetanide sodium (0.03-100 μM; 5 minutes) inhibits the 86Rb+ uptake in NKCC1A-expressing oocytes in a dose-dependent manner[1].
    Bumetanide sodium inhibits NKCC2 isoform B in HEK-293 cells with an IC50 value of 0.54 μM[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Bumetanide sodium Related Antibodies
    In Vivo

    Bumetanide sodium (7.6-30.4 mg/kg; i.v.) attenuates the decrease in apparent diffusion coefficients (ADC) ratios for both cortex and striatum (by 40-67%), indicating reduced edema formation[3].
    Bumetanide sodium also reduces infarct size[3].
    Bumetanide sodium shows different half-lives of 21.4 min, 53.8 min and 137 min following 2 mg/kg, 8 mg/kg and 20 mg/kg intravenous injection, respectively, in rats[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Klinische Studie
    Molekulargewicht

    386.40

    Formel

    C17H19N2NaO5S
    CAS. Nr.
    SMILES

    O=C(O[Na])C1=CC(NCCCC)=C(OC2=CC=CC=C2)C(S(=O)(N)=O)=C1
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung

    Please store the product under the recommended conditions in the Certificate of Analysis.
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    Bumetanide sodium Related Classifications

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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    C1   V1   C2   V2
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Bumetanide28434-74-4Ro 10-6338PF 1593PF1593PF-1593NKCCNa-K-Cl cotransporterNa(+)-K(+)-Cl(-) cotransporterNa+-K+-Cl− cotransporterneonatalseizuresdiureticcotransporterNKCC1NKCC2MCAOmiddlecerebralarteryocclusionInhibitorinhibitorinhibit

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