28434-74-4
28434-74-4
Chemical Structure
Bumetanide sodium
Synonym(s): Ro 10-6338 sodium; PF 1593 sodium
- CAS No.: 28434-74-4
- Formula:C17H19N2NaO5S
- Molecular Weight:386.40
IUPAC Name: sodium 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoate
InChIKey: QDFGOJHAQZEYQL-UHFFFAOYSA-M
SMILES: O=C(O[Na])C1=CC(NCCCC)=C(OC2=CC=CC=C2)C(S(=O)(N)=O)=C1
Biological Activity: Bumetanide sodium, a highly potent loop diuretic, is a Na+-K+-Cl+ cotransporter (NKCC) blocker. Bumetanide sodium is a selective NKCC1 inhibitor, and also inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1][2].
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Bumetanide sodium | Bumetanide sodium, a highly potent loop diuretic, is a Na+-K+-Cl+ cotransporter (NKCC) blocker. Bumetanide sodium is a selective NKCC1 inhibitor, and also inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively. | |||||||||||||||||||||
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References
- [1]. Lykke K, et al. The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A. Epilepsy Behav. 2016 Jun;59: [Content Brief]
- [2]. Ciaran Richardson, et al. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci. 2011 Mar 1;124(Pt 5):789-800. [Content Brief]
