cFMS Receptor Inhibitor II

Name: cFMS Receptor Inhibitor II
Brand: MedChemExpress
SKU: HY-112451
Rating: 4.5 (0 reviews)

製品番号: HY-112451 純度: 99.88%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor. CSF-1 is a cytokine.

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cFMS Receptor Inhibitor II 構造式

CAS 番号 : 959860-85-6

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 132	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 132	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$120	在庫あり	Estimated Time of Arrival: December 31
10 mg	$190	在庫あり	Estimated Time of Arrival: December 31
25 mg	$342	在庫あり	Estimated Time of Arrival: December 31
50 mg	$490	在庫あり	Estimated Time of Arrival: December 31
100 mg	$695	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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製品説明

cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor. CSF-1 is a cytokine^[1].

IC₅₀ & Target

CSF1R^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
NSO	IC₅₀	>50 μM Compound: 7f	Growth inhibition of MCSF-independent mouse NSO cells Growth inhibition of MCSF-independent mouse NSO cells	[PMID: 17870531]

分子量

368.43

分子式

C₂₃H₂₀N₄O

CAS 番号

959860-85-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(NC2=CC=C(C)C(C)=C2)C3=CC=C(C4=CC=NC=C4)C=C3N=C1)N

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 83.33 mg/mL (226.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7142 mL	13.5711 mL	27.1422 mL
5 mM	0.5428 mL	2.7142 mL	5.4284 mL
10 mM	0.2714 mL	1.3571 mL	2.7142 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.88%

Select Batch:

データシート (273 KB) SDS (393 KB)

COA (251 KB) LCMS (125 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Brenton John SHORT, et al. Compositions and methods for obtaining enriched mesenchymal stem cell cultures. US20160032248A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7142 mL	13.5711 mL	27.1422 mL	67.8555 mL
	5 mM	0.5428 mL	2.7142 mL	5.4284 mL	13.5711 mL
	10 mM	0.2714 mL	1.3571 mL	2.7142 mL	6.7855 mL
	15 mM	0.1809 mL	0.9047 mL	1.8095 mL	4.5237 mL
	20 mM	0.1357 mL	0.6786 mL	1.3571 mL	3.3928 mL
	25 mM	0.1086 mL	0.5428 mL	1.0857 mL	2.7142 mL
	30 mM	0.0905 mL	0.4524 mL	0.9047 mL	2.2618 mL
	40 mM	0.0679 mL	0.3393 mL	0.6786 mL	1.6964 mL
	50 mM	0.0543 mL	0.2714 mL	0.5428 mL	1.3571 mL
	60 mM	0.0452 mL	0.2262 mL	0.4524 mL	1.1309 mL
	80 mM	0.0339 mL	0.1696 mL	0.3393 mL	0.8482 mL
	100 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.6786 mL