2. Epigenetics
  3. Epigenetic Reader Domain
  4. cis-Revumenib

cis-Revumenib  (Synonyms: cis-SNDX-5613)

製品番号: HY-136175B 純度: 98.92%
COA 取扱説明書 Technical Support

cis-Revumenib (cis-SNDX-5613) is an isomer of Revumenib (HY-136175). Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

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cis-Revumenib

cis-Revumenib 構造式

容量 価格（税別） 在庫状況 数量
5 mg $190 在庫あり
10 mg $320 在庫あり
25 mg $630 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of cis-Revumenib:

cis-Revumenib 関連抗体

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製品説明

cis-Revumenib (cis-SNDX-5613) is an isomer of Revumenib (HY-136175). Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].

体内実験

Revumenib (HY-136175) shows in vivo plasma IC50 of 53 nM. Revumenib treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

630.82

分子式

C32H47FN6O4S
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(CC)C(C)C)C1=CC(F)=CC=C1OC2=CN=CN=C2N3CC4(CCN(C[C@H]5CC[C@@H](NS(=O)(CC)=O)CC5)CC4)C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (158.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5852 mL 7.9262 mL 15.8524 mL
5 mM 0.3170 mL 1.5852 mL 3.1705 mL
10 mM 0.1585 mL 0.7926 mL 1.5852 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5852 mL 7.9262 mL 15.8524 mL 39.6310 mL
5 mM 0.3170 mL 1.5852 mL 3.1705 mL 7.9262 mL
10 mM 0.1585 mL 0.7926 mL 1.5852 mL 3.9631 mL
15 mM 0.1057 mL 0.5284 mL 1.0568 mL 2.6421 mL
20 mM 0.0793 mL 0.3963 mL 0.7926 mL 1.9815 mL
25 mM 0.0634 mL 0.3170 mL 0.6341 mL 1.5852 mL
30 mM 0.0528 mL 0.2642 mL 0.5284 mL 1.3210 mL
40 mM 0.0396 mL 0.1982 mL 0.3963 mL 0.9908 mL
50 mM 0.0317 mL 0.1585 mL 0.3170 mL 0.7926 mL
60 mM 0.0264 mL 0.1321 mL 0.2642 mL 0.6605 mL
80 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.4954 mL
100 mM 0.0159 mL 0.0793 mL 0.1585 mL 0.3963 mL
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cis-Revumenib Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-Revumenibcis-SNDX-5613Epigenetic Reader DomainInhibitorinhibitorinhibit

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製品名:
cis-Revumenib
製品番号:
HY-136175B
数量:
MCE 日本正規代理店:

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