Cobalt protoporphyrin IX  (Synonyms: Co-PPIX)

Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV)^[1].

Cobalt protoporphyrin IX (2 μM; 0-24 h) increases the intracellular protein levels of HO-1 in a time-dependent manner in MDCK cells and RAW264.7 cells^[1].
Cobalt protoporphyrin IX shows antiviral activity against influenza viruses with IC₅₀s of 0.40 ± 0.16, 0.42 ± 0.15, 0.46 ± 0.19, 0.34 ± 0.05 and 0.64 ± 0.30 μM against Empty Cell A/FortMonmouth /1/1947, A/TianjinJinnan /15/2009, A/Wuhan /359/1995, A/FujianTongan /196/2009 and BY/FujianXinluo /54/2006, respectively^[1].
Cobalt protoporphyrin IX (0.25-2 μM; 18 or 24 h) inhibits IAV replication through augmenting IFN response, and the anti-IAV activity is not dependent on the catalytic function of HO-1^[1].
Anti-IAV activity of HO-1 induced by Cobalt protoporphyrin IX (2 μM; 0-6 h) may depend on IRF3 phosphorylation and translocation, in order to enhance antiviral IFN response^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

619.58

C₃₄H₃₂CoN₄O₄

14325-03-2

Solid

Brown to black

CC1=C(CCC([O-])=O)C2=CC(C(CCC([O-])=O)=C3C)=[N]4C3=CC5=C(C)C(C=C)=C6C=C(C(C)=C7C=C)[N]8=C7C=C1[N-]2[Co+2]84[N-]56.[H+].[H+]

Room temperature in continental US; may vary elsewhere.

• [1]. Ma LL, et al. heme oxygenase-1 agonist CoPP suppresses influenza virus replication through IRF3-mediated generation of IFN-α/β. Virology. 2019 Feb;528:80-88.  [Content Brief]