2. Neuronal Signaling
  3. Amyloid-β
  4. CRANAD-2

CRANAD-2 is a specific near-infrared (NIR) fluorescent probe for detecting Aβ plaques (unbound to Aβ: Ex=640 nm; Em=805 nm; after binding: Em=715 nm). CRANAD-2 penetrates the blood-brain barrier and has high affinity for Aβ aggregates, with a Kd value of 38 nM. CRANAD-2 is applicable to research related to Alzheimer's disease and neurodegenerative diseases.

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CRANAD-2

CRANAD-2 Chemische Struktur

CAS. Nr. : 1193447-34-5

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CRANAD-2 Related Antibodies

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Beschreibung

CRANAD-2 is a specific near-infrared (NIR) fluorescent probe for detecting Aβ plaques (unbound to Aβ: Ex=640 nm; Em=805 nm; after binding: Em=715 nm). CRANAD-2 penetrates the blood-brain barrier and has high affinity for Aβ aggregates, with a Kd value of 38 nM. CRANAD-2 is applicable to research related to Alzheimer's disease and neurodegenerative diseases[1][2][3][4].

In Vitro

CRANAD-2 (0-1500 nM; 1 h) binds to preformed ΔN amyloid fibrils with a dissociation constant of 55 ± 6 nM[1].
CRANAD-2 (35 nM) enables SMLM super-resolution imaging of preformed ΔN amyloid fibrils at a concentration of 35 nM, with a resolution of 45-55 nm[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRANAD-2 Related Antibodies
In Vivo

CRANAD-2 (2.0 mg/kg; i.v.; single dose) enables in vivo detection of Aβ deposits in the arcAβ mouse model via MSOT and epi-fluorescence imaging, with specific co-localization to Aβ deposits in brain sections[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: transgenic arcAβ mice (overexpressing human APP695 with Swedish and Arctic mutations, both sexes, 18-24 months-of-age); non-transgenic littermates (both sexes, 18-24 months-of-age)[2]
Dosage: 2.0 mg/kg
Administration: i.v.; single dose
Result: Exhibited higher cortical retention in arcAβ mice compared to non-transgenic littermates at 60-120 minutes post-injection; Co-localized with anti-Aβ antibodies in parenchymal and vessel-associated Aβ deposits in arcAβ mouse brain sections.
Showed no detectable signal in non-transgenic littermate cortex sections.
Molekulargewicht

410.26

Formel

C23H25BF2N2O2
CAS. Nr.
Appearance

Solid

Color

Brown to black

SMILES

CN(C)C(C=C1)=CC=C1/C=C/C2=O[B+3]([F-])([F-])O=C(/C=C/C3=CC=C(N(C)C)C=C3)[CH-]2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 2.08 mg/mL (5.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 2 mg/mL (4.87 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4375 mL 12.1874 mL 24.3748 mL
5 mM 0.4875 mL 2.4375 mL 4.8750 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 98.0%

SDS (393 KB)

COA (244 KB) HNMR (271 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / DMSO 1 mM 2.4375 mL 12.1874 mL 24.3748 mL 60.9370 mL
DMSO 5 mM 0.4875 mL 2.4375 mL 4.8750 mL 12.1874 mL
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CRANAD-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRANAD-21193447-34-5CRANAD2CRANAD 2Amyloid-ββ-amyloid peptideAβAbetaarcAβ mouse modelmouse brainInhibitorinhibitorinhibit

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