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  4. D-Biotinol

D-Biotinol is an orally active alcohol analogue of D-Biotin (HY-B0511). D-Biotinol can replace D-Biotin to restore the biotin deficiency induced by egg whites in rats. D-Biotinol can be used for the study of biotin deficiency disorders.

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D-Biotinol

D-Biotinol 構造式

CAS 番号 : 53906-36-8

容量 価格（税別） 在庫状況 数量
5 mg $70 在庫あり
10 mg $120 在庫あり
25 mg $250 在庫あり
50 mg $450 在庫あり
100 mg $750 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

Other Forms of D-Biotinol:

D-Biotinol 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

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製品説明

D-Biotinol is an orally active alcohol analogue of D-Biotin (HY-B0511). D-Biotinol can replace D-Biotin to restore the biotin deficiency induced by egg whites in rats. D-Biotinol can be used for the study of biotin deficiency disorders[1].

体外実験

D-Biotinol cannot replace biotin for the nutrition of microorganisms (such as Lactobacillus arabinosus, Lactobacillus casei, and Saccharomyces cerevisiae), as these microorganisms are unable to convert it into active biotin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Biotinol 関連抗体
体内実験

D-Biotinol (0.75-1.5 μg, p.o., three times a week for 4 weeks) is as effective as an equal amount of D-biotin in promoting growth and treating deficiency disorders in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Biotin deficiency model established in rats[1]
Dosage: 0.75 and 1.5 μg
Administration: Oral administration (p.o.), three times a week for 4 weeks
Result: Increased the weight of rats and alleviated the symptoms of deficiencies (such as dermatitis, hair loss).
分子量

230.33

分子式

C10H18N2O2S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OCCCCC[C@H]1[C@](N2)([H])[C@@](CS1)([H])NC2=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (434.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Methanol : 25 mg/mL (108.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3416 mL 21.7080 mL 43.4160 mL
5 mM 0.8683 mL 4.3416 mL 8.6832 mL
10 mM 0.4342 mL 2.1708 mL 4.3416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (10.85 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol / DMSO 1 mM 4.3416 mL 21.7080 mL 43.4160 mL 108.5399 mL
5 mM 0.8683 mL 4.3416 mL 8.6832 mL 21.7080 mL
10 mM 0.4342 mL 2.1708 mL 4.3416 mL 10.8540 mL
15 mM 0.2894 mL 1.4472 mL 2.8944 mL 7.2360 mL
20 mM 0.2171 mL 1.0854 mL 2.1708 mL 5.4270 mL
25 mM 0.1737 mL 0.8683 mL 1.7366 mL 4.3416 mL
30 mM 0.1447 mL 0.7236 mL 1.4472 mL 3.6180 mL
40 mM 0.1085 mL 0.5427 mL 1.0854 mL 2.7135 mL
50 mM 0.0868 mL 0.4342 mL 0.8683 mL 2.1708 mL
60 mM 0.0724 mL 0.3618 mL 0.7236 mL 1.8090 mL
80 mM 0.0543 mL 0.2713 mL 0.5427 mL 1.3567 mL
100 mM 0.0434 mL 0.2171 mL 0.4342 mL 1.0854 mL
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D-Biotinol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Biotinol53906-36-8Drug DerivativeDrug derivativeLactobacillus arabinosusSaccharomyces cerevisiaeL. caseiD-biotinegg white induced biotin deficiencyInhibitorinhibitorinhibit

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製品名:
D-Biotinol
製品番号:
HY-W096159
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