Diallyl tetrasulfide

Name: Diallyl tetrasulfide
Brand: MedChemExpress
SKU: HY-N9515
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Cat. No.: HY-N9515: Ficha de datos Instrucciones de manejo
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Diallyl tetrasulfide is an orally active diallyl tetrasulfide. Diallyl tetrasulfide ameliorates cadmium-induced changes in acetylcholinesterase and adenosine triphosphatase activities as well as oxidative stress injury in the brain of rats. Diallyl tetrasulfide inhibits lipid peroxidation in rat liver microsomes. Diallyl tetrasulfide ameliorates cadmium-induced oxidative liver injury in rats. Diallyl tetrasulfide protects cells against cadmium-induced loss of cell viability, reduces apoptosis rate and ROS production. Diallyl tetrasulfide is applicable to research related to cadmium-induced neurotoxicity and cadmium-induced oxidative liver injury.

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Diallyl tetrasulfide Estructura química

No. CAS : 2444-49-7

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
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50 mg	Obtener un presupuesto

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Descripciòn

In Vitro

Diallyl tetrasulfide (25 μg/mL; 3 h) inhibits lipid peroxidation when co-incubated with rat liver microsomes treated with ascorbic acid/Fe²⁺^[2].
Diallyl tetrasulfide (5-50 μg/mL; 18 h) dose-dependently protects Vero cells against cadmium-induced loss of cell viability^[4].
Diallyl tetrasulfide (40 μg/mL; 18 h) reduces the cadmium-induced apoptosis rate of Vero cells by 75%, decreases the intracellular accumulation of superoxide anions and hydrogen peroxide, and protects cells from cadmium-induced loss of mitochondrial membrane potential^[4].
Diallyl tetrasulfide (10-40 μg/mL; 30 min) significantly reduces cadmium-induced intracellular ROS production in Vero cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	Vero cells
Concentration:	5, 10, 20, 30, 40, 50 μg/mL
Incubation Time:	18 h
Result:	Attenuated cadmium-induced suppression of cell viability in a dose-dependent manner. Reached 87% cell survival rate at 50 μg/mL. Showed a highly significant increase to 86% viability at 40 μg/mL. Did not affect cell viability when used alone at 50 μg/mL.

Apoptosis Analysis^[4]

Cell Line:	Vero cells
Concentration:	40 μg/mL
Incubation Time:	18 h
Result:	Prevented cadmium-induced apoptotic nuclear changes (condensed or fragmented nuclei). Reduced cadmium-induced apoptosis by 75% relative to cadmium-only treated cells. Showed intact, healthy nuclei with no significant increase in apoptosis compared to control when used alone at 40 μg/mL.

In Vivo

Diallyl tetrasulfide (10-40 mg/kg, p.o., daily, for 3 weeks) significantly alleviates cadmium-induced oxidative stress, acetylcholinesterase inhibition and membrane ATPase dysfunction in the brain of rats, restores the activities of liver marker enzymes to normal levels, reduces cadmium accumulation and the levels of oxidative stress markers in the liver, restores the antioxidant defense system, and improves hepatic histopathological changes^[1]^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar rats (male, initial body weight 170-200 g, cadmium-induced neurotoxicity/Liver oxidative damage model)^[1]
Dosage:	10 mg/kg; 20 mg/kg; 40 mg/kg
Administration:	p.o.; daily; 3 weeks
Result:	Reversed brain acetylcholinesterase activity to near normal levels. Reduced brain lipid peroxidation markers to 14.10 μmol/g tissue (TBARS) and 1.20 mmol/g tissue (LOOH). Reduced brain protein carbonyl levels to 4.25 nmol/mg protein. Increased brain reduced glutathione levels to 2.65 μg/mg protein and total sulphydryl groups to 7.06 μg/mg protein. Restored brain superoxide dismutase activity to 8.24 units, catalase activity to 3.79 μmol H₂O₂ consumed/min, glutathione peroxidase activity to 3.05 μg glutathione consumed/min/mg protein, and glutathione-S-transferase activity to 5.78 μmol CDNB-GSH conjugate formed/min/mg protein. Restored brain total ATPases activity to 1.35 μg Pi liberated/min/mg protein, Na⁺K⁺-ATPase activity to 0.36 μg Pi liberated/min/mg protein, Ca²⁺-ATPase activity to 0.384 μg Pi liberated/min/mg protein, and Mg²⁺-ATPase activity to 0.28 μg Pi liberated/min/mg protein. Normalized serum activities of hepatic marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase) in a dose-dependent manner, with greater efficacy at 40 mg/kg than 10 mg/kg and 20 mg/kg. Reduced liver cadmium accumulation from 500 μg/g wet tissue to 200 μg/g wet tissue. Decreased liver thiobarbituric acid reactive substances to 0.125 nmol/mg protein, hydroperoxides to 0.96 mmol/g tissue, and protein carbonyl levels to 3.19 nmol/mg protein. Restored liver non-enzymic antioxidant levels: reduced glutathione to 3.03 μg/mg protein, total thiols to 13.65 μg/mg protein, vitamin C to 1.20 μmol/mg tissue, and vitamin E to 0.61 μmol/mg tissue. Restored liver enzymic antioxidant and glutathione metabolising enzyme activities: superoxide dismutase to 6.30 U/mg protein, catalase to 72.86 U/mg protein, glutathione peroxidase to 5.43 U/mg protein, glutathione-S-transferase to 6.07 U/mg protein, glutathione reductase to 0.43 U/mg protein, and glucose-6-phosphate dehydrogenase to 1.88 U/mg protein. Improved liver histopathology, resulting in normal hepatocytes with mild portal inflammation.

Peso molecular

210.40

Fòrmula

C₆H₁₀S₄

No. CAS

2444-49-7

SMILES

C=CCSSSSCC=C

Structure Classification

Others

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Pari L, et al. Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats. Toxicology. 2007;234(1-2):44-50. [Content Brief]

[2]. Toshiharu Horie, et al. Identified Diallyl Polysulfides from an Aged Garlic Extract which Protects the Membranes from Lipid Peroxidation. Planta Med 1992; 58(5): 468-469.

[3]. Murugavel P, et al. Effects of diallyl tetrasulfide on cadmium-induced oxidative damage in the liver of rats. Hum Exp Toxicol. 2007;26(6):527-534. [Content Brief]

[4]. Murugavel P, et al. Cadmium induced mitochondrial injury and apoptosis in vero cells: protective effect of diallyl tetrasufide from garlic. Int J Biochem Cell Biol. 2007;39(1):161-170. [Content Brief]