Dimethyl succinate

Name: Dimethyl succinate
Brand: MedChemExpress
SKU: HY-Y0808
Rating: 4.5 (1 reviews)

製品番号: HY-Y0808 純度: 99.95%: Data Sheet SDS COA 取扱説明書
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Dimethyl succinate is an orally active cell permeable succinate analogue. Dimethyl succinate can disrupt the TCA cycle by elevating intracellular succinate levels, leading to reduced protein synthesis and impairs myogenic differentiation. Dimethyl succinate can induce apoptosis. Dimethyl succinate can decrease maximal cellular respiration and reserve capacity. Dimethyl succinate can rescue synapse loss in AD. Dimethyl succinate can be used for the researches of metabolic and neurological disease^[1][2].

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 106-65-0

容量	価格（税別）	在庫状況	数量
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solid or liquid
500 mg	$50	在庫あり	Estimated Time of Arrival: December 31
1 g	$73	在庫あり	Estimated Time of Arrival: December 31
5 g	$176	在庫あり	Estimated Time of Arrival: December 31
10 g	$230	在庫あり	Estimated Time of Arrival: December 31
50 g		お問い合わせ

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This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of Dimethyl succinate:

Dimethyl succinate-d₄ 在庫あり

顧客検証

•Chin Med. 2024 May 13;19(1):68. [Abstract]

Flow Cytometry

: Dimethyl succinate purchased from MedChemExpress. Usage Cited in: Chin Med. 2024 May 13;19(1):68. [Abstract]; Dimethyl succinate (DES) (5 mM; 72 h) reversed the decrease of CD44 expression and proliferation of CD4⁺ T cells by acacetin.

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純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

Dimethyl succinate (16 mM) increases apoptotic cells in C2C12 myoblasts^[1].
Dimethyl succinate (4-8 mM, 48 h) increases intracellular succinate, malate and glutamate in C2C12 myoblasts^[1]. Dimethyl succinate (8 mM, 48 h) reduces protein anabolism as determined by an O-propargyl-puromycin (OPP) incorporation assay in C2C12 myoblasts^[1]. Dimethyl succinate (8 mM) reduces maximal respiration and mitochondria reserve capacity in C2C12 myoblasts^[1]. Dimethyl succinate (8 mM) results in an impaired ability to form mature, multinucleated Myosin Heavy Chain-positive structures in C2C12 myoblasts^[1]. Dimethyl succinate (5 mM, 48 h) partially rescues synapse loss in AD hiPSC-derived cerebrocortical neurons^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	C2C12 myoblasts
Concentration:	4 mM, 8 mM, 16 mM
Incubation Time:	48 hours
Result:	Showed no significant differences in proliferation over this time period.

Apoptosis Analysis^[1]

Cell Line:	C2C12 myoblasts
Concentration:	4 mM, 8 mM, 16 mM
Incubation Time:	48 hours
Result:	Only increased apoptosis rates at 16 mM.

体内実験

Dimethyl succinate (2% in water, p.o., 6 weeks) impairs skeletal muscle homeostasis and regeneration, leading to smaller muscle myofiber diameters^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	FVB mice; wild type model^[1]
Dosage:	2% in water
Administration:	Oral; 6 weeks
Result:	Had no significant difference in total body weight and total lean mass. Impaired skeletal muscle homeostasis and regeneration. Exhibited smaller muscle myofiber diameters.

分子量

146.14

分子式

C₆H₁₀O₄

CAS 番号

106-65-0

Appearance

<16°C Solid,>19°C Liquid

Color

Colorless to off-white

SMILES

O=C(OC)CCC(OC)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 200 mg/mL (1368.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (684.28 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.8428 mL	34.2138 mL	68.4275 mL
5 mM	1.3686 mL	6.8428 mL	13.6855 mL
10 mM	0.6843 mL	3.4214 mL	6.8428 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Saline
Solubility: ≥ 100 mg/mL (684.28 mM); Clear solution

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.95%

Select Batch:

データシート (274 KB) SDS (393 KB)

COA (244 KB) HNMR (127 KB) GC (209 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Arneson-Wissink PC, et al. The wasting-associated metabolite succinate disrupts myogenesis and impairs skeletal muscle regeneration. JCSM Rapid Commun. 2020;3(2):56-69. [Content Brief]

[2]. Andreyev AY, et al. Metabolic Bypass Rescues Aberrant S-nitrosylation-Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons. Adv Sci (Weinh). 2024;11(12):e2306469. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	6.8428 mL	34.2138 mL	68.4275 mL	171.0688 mL
	5 mM	1.3686 mL	6.8428 mL	13.6855 mL	34.2138 mL
	10 mM	0.6843 mL	3.4214 mL	6.8428 mL	17.1069 mL
	15 mM	0.4562 mL	2.2809 mL	4.5618 mL	11.4046 mL
	20 mM	0.3421 mL	1.7107 mL	3.4214 mL	8.5534 mL
	25 mM	0.2737 mL	1.3686 mL	2.7371 mL	6.8428 mL
	30 mM	0.2281 mL	1.1405 mL	2.2809 mL	5.7023 mL
	40 mM	0.1711 mL	0.8553 mL	1.7107 mL	4.2767 mL
	50 mM	0.1369 mL	0.6843 mL	1.3686 mL	3.4214 mL
	60 mM	0.1140 mL	0.5702 mL	1.1405 mL	2.8511 mL
	80 mM	0.0855 mL	0.4277 mL	0.8553 mL	2.1384 mL
	100 mM	0.0684 mL	0.3421 mL	0.6843 mL	1.7107 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.