2. Disease Areas
  3. Infection
  4. Viral Infection
  5. Rabies Virus Infection

Rabies Virus Infection

Rabies virus is a highly neurotropic, enveloped, single-stranded RNA virus belonging to the Rhabdoviridae family, genus Lyssavirus, causing an acute and invariably fatal infection of the central nervous system in humans and other mammals, primarily transmitted through bites from infected animals, especially bats in the Americas. It selectively infects neurons and is widely used in neuroscience as a retrograde tracer due to its ability to travel along axons; however, its high neurotoxicity limits its use unless modified to restrict replication and neuronal tropism. Pseudorabies virus (PRV), also known as Aujeszky's disease virus, is a member of the Herpesviridae family that causes severe reproductive and neurological disease in pigs, leading to abortion, stillbirths, and mummified fetuses, resulting in major economic losses in swine production.

References:

Rabies Virus Infection (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N14107
    Cinnabarin 146-90-7
    Cinnabarin is a natural phenoxazinone red pigment derived from Pycnoporus sanguineus. Cinnabarin reduces rabies virus infection levels in neuroblastoma cells and causes cytopathic effects on neuroblastoma cell monolayers at high concentrations. Cinnabarin exhibits antibacterial activity against bacteria, with a preference for Gram-positive bacteria and human isolates. Cinnabarin can be used in studies related to rabies and drug-resistant Gram-positive bacteria.
    Cinnabarin
  • HY-P4098
    SynB1 1207092-86-1 99.96%
    SynB1 is a cell-penetrating peptide with blood-brain barrier permeability, derived from the antimicrobial peptide Protegrin 1. SynB1 enhances the cellular uptake efficiency and cytoplasmic localization level of conjugated constructs. SynB1 can be used in studies related to rabies and glioblastoma.
    SynB1
  • HY-182464
    DABMA 893603-33-3
    DABMA is a TMEM175 channel activator with a human EC50 of 17.9 μM. DABMA directly increases TMEM175 channel current via interaction with intracellular, transmembrane, or endosomal lumen-associated domains, and does not alter TMEM175 mRNA or protein levels. DABMA delays endolysosomal substrate degradation, modulates endolysosomal trafficking, increases acidic organelle accumulation, induces cholesterol accumulation and altered late endosome morphology. DABMA can be used for the research of coronavirus disease, Clostridium difficile infection, Pseudomonas aeruginosa infection, rabies, and influenza virus infection.
    DABMA