2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Endogenous Metabolite
  4. Cinnabarin

Cinnabarin is a natural phenoxazinone red pigment derived from Pycnoporus sanguineus. Cinnabarin reduces rabies virus infection levels in neuroblastoma cells and causes cytopathic effects on neuroblastoma cell monolayers at high concentrations. Cinnabarin exhibits antibacterial activity against bacteria, with a preference for Gram-positive bacteria and human isolates. Cinnabarin can be used in studies related to rabies and drug-resistant Gram-positive bacteria.

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Cinnabarin

Cinnabarin Chemical Structure

CAS No. : 146-90-7

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Cinnabarin Related Antibodies

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Description

Cinnabarin is a natural phenoxazinone red pigment derived from Pycnoporus sanguineus. Cinnabarin reduces rabies virus infection levels in neuroblastoma cells and causes cytopathic effects on neuroblastoma cell monolayers at high concentrations. Cinnabarin exhibits antibacterial activity against bacteria, with a preference for Gram-positive bacteria and human isolates. Cinnabarin can be used in studies related to rabies and drug-resistant Gram-positive bacteria[1].

In Vitro

Cinnabarin (0.155-5.0 mg/mL; 24 h) exhibits no cytotoxic effects on mouse neuroblastoma NA cells at 0.31 mg/mL or lower, but causes dose-dependent cytopathic effects at concentrations of 0.62 mg/mL and higher, affecting over 50% of cells at 2.5 mg/mL and above[1].
Cinnabarin (0.155-5.0 mg/mL; 24 h) reduces rabies virus infection in mouse neuroblastoma NA cells in a dose-dependent manner, achieving a four-fold reduction in viral titers at a concentration of 0.31 mg/mL; no viral titer results are reported for concentrations of 0.62 mg/mL and higher[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cinnabarin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: mouse neuroblastoma NA cells (ATCC clone C-1300)
Concentration: 0.155 mg/mL, 0.31 mg/mL, 0.62 mg/mL, 1.25 mg/mL, 2.5 mg/mL, 5.0 mg/mL
Incubation Time: 24 h
Result: Showed no effect on NA cell monolayers at concentrations up to 0.31 mg/mL.
Caused small cytopathic effects affecting 10% of cells at 0.62 mg/mL.
Induced cytopathic effects affecting 25% of cells at 1.25 mg/mL.
Provoked intense morphological alterations affecting more than 50% of cells at 2.5 mg/mL and 5.0 mg/mL.
In Vivo

Cinnabarin (220-1000 mg/kg; i.p.; single dose) causes no detectable mortality or organ toxicity in male Swiss mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice (male, 2 months old, 18-22 g)[1]
Dosage: 220 mg/kg; 380 mg/kg; 720 mg/kg; 1000 mg/kg
Administration: i.p.; single dose
Result: Caused no mortality in mice.
Showed no macroscopic or microscopic alterations (including inflammation, granulomas, or lesions) in liver, kidney, thymus, spleen, or heart tissue relative to vehicle controls.
Molecular Weight

286.24

Formula

C14H10N2O5
CAS No.
SMILES

O=C(C(C1=NC2=C(CO)C=CC=C2OC1=C3)=C(N)C3=O)O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Cinnabarin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinnabarin146-90-7BacterialEndogenous Metabolitemouse neuroblastoma NA cellsGram-positive bacteriahuman-isolated bacterianeuroblastoma cellsPycnoporus sanguineusrabies virusmale Swiss miceInhibitorinhibitorinhibit

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