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  3. Peptide and Derivatives
  4. Peptides for Drug Delivery
  5. Cell-penetrating Peptides
  6. SynB1

SynB1 is a cell-penetrating peptide with blood-brain barrier permeability, derived from the antimicrobial peptide Protegrin 1. SynB1 enhances the cellular uptake efficiency and cytoplasmic localization level of conjugated constructs. SynB1 can be used in studies related to rabies and glioblastoma.

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Custom Peptide Synthesis

SynB1

SynB1 Chemical Structure

CAS No. : 1207092-86-1

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Based on 1 publication(s) in Google Scholar

SynB1 Related Antibodies

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  • Purity & Documentation

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Description

SynB1 is a cell-penetrating peptide with blood-brain barrier permeability, derived from the antimicrobial peptide Protegrin 1. SynB1 enhances the cellular uptake efficiency and cytoplasmic localization level of conjugated constructs. SynB1 can be used in studies related to rabies and glioblastoma[2].

In Vitro

SynB1 can conjugate with rabies virus-neutralizing antibodies, and physically and chemically "pull" the neutralizing antibodies, which are originally blocked from entering the brain, into the brain, thereby achieving neutralization and clearance of the lethal rabies virus[1].
SynB1 enhances the delivery efficiency of a Notch inhibitory peptide (dnMAML) to glioblastoma cells and facilitates its penetration of the blood-brain barrier[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SynB1 Related Antibodies
Molecular Weight

2171.38

Formula

C89H151N37O27
CAS No.
Appearance

Solid

Color

White to light yellow

Sequence

Arg-Gly-Gly-Arg-Leu-Ser-Tyr-Ser-Arg-Arg-Arg-Phe-Ser-Thr-Ser-Thr-Gly-Arg-Ala
Sequence Shortening

RGGRLSYSRRRFSTSTGRA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (46.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4605 mL 2.3027 mL 4.6054 mL
5 mM 0.0921 mL 0.4605 mL 0.9211 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.4605 mL 2.3027 mL 4.6054 mL 11.5134 mL
5 mM 0.0921 mL 0.4605 mL 0.9211 mL 2.3027 mL
10 mM 0.0461 mL 0.2303 mL 0.4605 mL 1.1513 mL
15 mM 0.0307 mL 0.1535 mL 0.3070 mL 0.7676 mL
20 mM 0.0230 mL 0.1151 mL 0.2303 mL 0.5757 mL
25 mM 0.0184 mL 0.0921 mL 0.1842 mL 0.4605 mL
30 mM 0.0154 mL 0.0768 mL 0.1535 mL 0.3838 mL
40 mM 0.0115 mL 0.0576 mL 0.1151 mL 0.2878 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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SynB1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SynB11207092-86-1SynB 1SynB-1Othersblood-brain barriercell penetrating peptideglioblastomaSynB1-ELP1-dnMAML complexcytoplasmic localizationcellular uptakeInhibitorinhibitorinhibit

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