2. Disease Areas
  3. Infection
  4. Bacterial Infection
  5. Shigella Infection

Shigella Infection

Shigella infection is caused by Gram-negative, facultative anaerobic rods of the Enterobacteriaceae family, primarily transmitted via the fecal-oral route through contaminated food or water, resulting in a spectrum of disease from mild diarrhea to severe bacillary dysentery. Unlike Campylobacter jejuni, Shigella employs distinct molecular mechanisms for pathogenesis, characterized by actin-dependent invasion of intestinal mucosa through M cells via macropinocytosis, followed by rapid vacuolar membrane disruption and intracellular replication. The bacterium produces the IcsA protein, which nucleates actin tails that propel it through host cells, facilitating cell-to-cell spread. Internalization into submucosal monocytes triggers apoptosis and release of proinflammatory IL-1β, while infected epithelial cells secrete IL-8, recruiting lymphocytes from the lamina propria. The resulting tissue destruction and intense local inflammation underlie the clinical manifestations of dysentery.

References:

Shigella Infection (2):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-Y1055
    Guanine 73-40-5 98.0%
    Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects.
    Guanine
  • HY-Y1055A
    Guanine hydrochloride 635-39-2 98.78%
    Guanine hydrochloride is one of the fundamental components of nucleic acids (DNA and RNA). Guanine hydrochloride is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine hydrochloride has the potential to serve as a large-capacity N pool. Guanine hydrochloride has cytotoxic, antinociceptive and neuroprotective effects.
    Guanine hydrochloride