2. 疾患領域
  3. Inflammation or Immune System Disease
  4. Allergy Skin Inflammation
  5. Urticaria

Urticaria

Urticaria, commonly known as hives, is a skin condition characterized by the sudden appearance of itchy, red, raised welts or plaques that are typically well-circumscribed, erythematous, and pruritic. These weals are smooth, slightly elevated, and often migratory, appearing and disappearing in different locations over time. Urticaria results from an allergic reaction or other triggers such as infections, autoimmune disorders, stress, insect bites, food, or medications. It may be accompanied by angioedema, involving swelling of deeper tissues, particularly in the face, lips, tongue, or throat, which can lead to respiratory difficulty in severe cases. The rash usually resolves within minutes to days without leaving lasting skin changes, although chronic urticaria—lasting more than six weeks—occurs in less than 5% of cases and may recur. The lesions arise in the upper dermis and present as pale red, intensely itchy bumps that may burn or sting.

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Urticaria (10):

製品番号 製品名 CAS 番号 純度 構造式
  • HY-13568
    Benoxaprofen 51234-28-7 99.03%
    Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms.
    Benoxaprofen
  • HY-W010056
    Diethyl fumarate

    フマル酸ジエチル

    		623-91-6 98.97%
    Diethyl fumarate is a Nrf2 inducer. Diethyl fumarate induces non-immunological contact urticaria, causing erythema, edema, and dose-dependent skin responses characterized by rapid onset, peak response, and subsequent resolution. The hybrid of Diethyl fumarate and Curcumin (HY-N0005) exerts neuroprotective effects. Diethyl fumarate can be used in the research of Parkinson's disease and non-immunological contact urticaria.
    Diethyl fumarate
  • HY-17428
    Tripelennamine hydrochloride

    Tripelennamine hydrochloride

    		154-69-8 99.81%
    Tripelennamine hydrochloride is a histamine H1-receptor antagonist. Tripelennamine hydrochloride effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine hydrochloride does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine hydrochloride exhibits local and central analgesic activity. Tripelennamine hydrochloride can be used in studies related to emphysema, urticaria and acute laminitis.
    Tripelennamine hydrochloride
  • HY-17428R
    Tripelennamine hydrochloride (Standard) 154-69-8
    Tripelennamine hydrochloride (Standard) is the analytical standard of Tripelennamine hydrochloride (HY-17428). This product is intended for research and analytical applications. Tripelennamine hydrochloride is a histamine H1-receptor antagonist. Tripelennamine hydrochloride effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine hydrochloride does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine hydrochloride exhibits local and central analgesic activity. Tripelennamine hydrochloride can be used in studies related to emphysema, urticaria and acute laminitis.
    Tripelennamine hydrochloride (Standard)
  • HY-17428B
    Tripelennamine citrate 6138-56-3
    Tripelennamine citrate is a histamine H1-receptor antagonist. Tripelennamine citrate effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine citrate does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine citrate exhibits local and central analgesic activity. Tripelennamine citrate can be used in studies related to emphysema, urticaria and acute laminitis.
    Tripelennamine citrate
  • HY-180652
    c-Kit-IN-13 3041025-10-6
    c-Kit-IN-13 (Compound I) is a c-kit kinase inhibitor. c-Kit-IN-13 inhibits the autophosphorylation of wild-type c-kit, with an IC50 of 0.3 nM for pKIT. c-Kit-IN-13 inhibits Exon 11 KIT, with an IC50 of 0.9 nM. c-Kit-IN-13 can be used in the research of mast cell-mediated diseases such as urticaria.
    c-Kit-IN-13
  • HY-180653
    c-Kit-IN-14 3041025-49-1
    c-Kit-IN-14 (Compound 1) is a c-kit kinase inhibitor. c-Kit-IN-14 inhibits the phosphorylation of wild-type c-kit, with an IC50 of 0.4 nM for pKIT. c-Kit-IN-14 inhibits Exon 11 KIT, with an IC50 of 0.4 nM. c-Kit-IN-14 can be used in the research of mast cell-mediated diseases such as urticaria.
    c-Kit-IN-14
  • HY-17428A
    Tripelennamine 91-81-6
    Tripelennamine is a histamine H1-receptor antagonist. Tripelennamine effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine exhibits local and central analgesic activity. Tripelennamine can be used in studies related to emphysema, urticaria and acute laminitis.
    Tripelennamine
  • HY-124280
    Pyrethrosin 28272-18-6
    Pyrethrosin is a sesquiterpene lactone and skin-sensitizing substance (Sh).Pyrethrosin can be used for the research of contact eczema (skin sensitization).
    Pyrethrosin
  • HY-125137
    (R)-(-)-Chlorpheniramine maleate 23095-76-3
    (R)-(-)-Chlorpheniramine maleate is an enantiomer of Chlorpheniramine maleate (HY-B0286A). Chlorpheniramine maleate is a H1 antihistamines. (R)-(-)-Chlorpheniramine maleate can be used for allergic diseases such as rhinitis and urticaria research.
    (R)-(-)-Chlorpheniramine maleate