1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor
  3. Tripelennamine hydrochloride

Tripelennamine hydrochloride 

Cat. No.: HY-17428 Purity: 99.87%
Handling Instructions

Tripelennamine Hcl, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine.

For research use only. We do not sell to patients.

Tripelennamine hydrochloride Chemical Structure

Tripelennamine hydrochloride Chemical Structure

CAS No. : 154-69-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
100 mg USD 84 In-stock
Estimated Time of Arrival: December 31
200 mg USD 132 In-stock
Estimated Time of Arrival: December 31
500 mg USD 228 In-stock
Estimated Time of Arrival: December 31
1 g USD 312 In-stock
Estimated Time of Arrival: December 31
5 g USD 624 In-stock
Estimated Time of Arrival: December 31
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50 g   Get quote  

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Description

Tripelennamine Hcl, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine. IC50 Value: Target: Histamine H1 receptor Tripelennamine can be used in the treatment of asthma, hay fever, rhinitus and urticaria. in vitro: Arterial and mixed venous blood-gas and pH measurements were made at rest before and after saline or drug administration and during incremental exercise leading to maximal exertion at 14 m/s on 3.5% uphill grade for 120 s. Galloping at this workload elicited maximal heart rate and induced exercise-induced pulmonary hemorrhage in all horses in both treatments, thereby indicating that capillary stress failure-related pulmonary injury had occurred [1]. in vivo: The data obtained (median and range in brackets) in camels and horses, respectively, were as follows: the terminal elimination half-lives were 2.39 (1.91-6.54) and 2.08 (1.31-5.65) h, total body clearances were 0.97 (0.82-1.42) and 0.84 (0.64-1.17)L/h/kg. The volumes of distribution at steady state were 2.87 (1.59-6.67) and 1.69 (1.18-3.50) L/kg, the volumes of the central compartment of the two compartment pharmacokinetic model were 1.75 (0.68-2.27) and 1.06 (0.91-2.20) L/kg [2]. After intramuscular administration of 50 or 100 mg tripelennamine, mean plasma concentrations at 30 minutes were 105 and 194 ng/ml, respectively, and mean plasma t1/2 values were 2.9 and 4.4 hours, respectively [3].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (113.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4268 mL 17.1338 mL 34.2677 mL
5 mM 0.6854 mL 3.4268 mL 6.8535 mL
10 mM 0.3427 mL 1.7134 mL 3.4268 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

291.82

Formula

C₁₆H₂₂ClN₃

CAS No.

154-69-8

SMILES

CN(C)CCN(CC1=CC=CC=C1)C2=NC=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Tripelennamine hydrochloride
Cat. No.:
HY-17428
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Tripelennamine hydrochloride

Cat. No.: HY-17428