2. Protein Tyrosine Kinase/RTK
  3. c-Kit
  4. c-Kit-IN-14

c-Kit-IN-14 (Compound 1) is a c-kit kinase inhibitor. c-Kit-IN-14 inhibits the phosphorylation of wild-type c-kit, with an IC50 of 0.4 nM for pKIT. c-Kit-IN-14 inhibits Exon 11 KIT, with an IC50 of 0.4 nM. c-Kit-IN-14 can be used in the research of mast cell-mediated diseases such as urticaria.

For research use only. We do not sell to patients.

c-Kit-IN-14

c-Kit-IN-14 Chemical Structure

CAS No. : 3041025-49-1

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c-Kit-IN-14 Related Antibodies

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Description

c-Kit-IN-14 (Compound 1) is a c-kit kinase inhibitor. c-Kit-IN-14 inhibits the phosphorylation of wild-type c-kit, with an IC50 of 0.4 nM for pKIT. c-Kit-IN-14 inhibits Exon 11 KIT, with an IC50 of 0.4 nM. c-Kit-IN-14 can be used in the research of mast cell-mediated diseases such as urticaria[1].

IC50 & Target

IC50: 0.4 nM (pKIT); 0.4 nM (Exon 11 KIT)[1]
Molecular Weight

565.99

Formula

C26H25ClFN9O3
CAS No.
SMILES

COC[C@H](CN1C=C(C(C)=N1)C2=CC3=C(C=NN3C=C2)C(NC4=C(C=C(C(C5=NN(N=N5)C6CC6)=C4)F)Cl)=O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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c-Kit-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Kit-IN-143041025-49-1c-KitSCFRCD117mast cellurticariaHMC1.1Inhibitorinhibitorinhibit

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