2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. DM4-SMCC

DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker.

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DM4-SMCC

DM4-SMCC 화학구조

CAS No. : 1228105-52-9

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

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고객리뷰

Based on 1 Customer Validation

DM4-SMCC Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker[1].

IC50 & Target[1]

Maytansinoids

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DM4-SMCC Related Antibodies
분자량

1114.69

화학식

C54H72ClN5O16S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(C)(C)SC(C5)C(N(CC6CCC(C(ON7C(CCC7=O)=O)=O)CC6)C5=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 125 mg/mL (112.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8971 mL 4.4856 mL 8.9711 mL
5 mM 0.1794 mL 0.8971 mL 1.7942 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 96.86%

SDS (420 KB)

COA (257 KB) HNMR (376 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8971 mL 4.4856 mL 8.9711 mL 22.4278 mL
5 mM 0.1794 mL 0.8971 mL 1.7942 mL 4.4856 mL
10 mM 0.0897 mL 0.4486 mL 0.8971 mL 2.2428 mL
15 mM 0.0598 mL 0.2990 mL 0.5981 mL 1.4952 mL
20 mM 0.0449 mL 0.2243 mL 0.4486 mL 1.1214 mL
25 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8971 mL
30 mM 0.0299 mL 0.1495 mL 0.2990 mL 0.7476 mL
40 mM 0.0224 mL 0.1121 mL 0.2243 mL 0.5607 mL
50 mM 0.0179 mL 0.0897 mL 0.1794 mL 0.4486 mL
60 mM 0.0150 mL 0.0748 mL 0.1495 mL 0.3738 mL
80 mM 0.0112 mL 0.0561 mL 0.1121 mL 0.2803 mL
100 mM 0.0090 mL 0.0449 mL 0.0897 mL 0.2243 mL
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DM4-SMCC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DM4-SMCC1228105-52-9Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Inquiry Information

상품명:
DM4-SMCC
Cat. No.:
HY-126494
수량:
MCE Japan Authorized Agent:

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비고

SAFETY DATA SHEET (SDS)

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