2. Epigenetics
  3. Epigenetic Reader Domain
  4. DN02

DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8 (1) (Ki=32 nM), which is 30-fold more affinity than BRD8 (2) (Ki>1000 nM).

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DN02

DN02 Chemische Struktur

CAS. Nr. : 3055009-00-9

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10 mM * 1 mL in DMSO
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DN02 Related Antibodies

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Beschreibung

DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8 (1) (Ki=32 nM), which is 30-fold more affinity than BRD8 (2) (Ki>1000 nM)[1].

In Vitro

DN02 has (1 nM-100 μM) low nM AlphaScreen with IC50 value of 48 nM, with high selectivity over BRD9 and BRD4 in biochemical AlphaScreen assays[1].
DN02 (32 nM) has minimal off-target engagement across the bromodomain family, with modest activity against CBP/P300[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DN02 Related Antibodies
Molekulargewicht

397.44

Formel

C22H24FN3O3
CAS. Nr.
Appearance

Solid

Color

White to yellow

SMILES

O=C1N(C)C=C(C2=C(OC)C=C(CN3CC(N)C3)C=C2OC)C4=C1C=C(F)C=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 100 mg/mL (251.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5161 mL 12.5805 mL 25.1610 mL
5 mM 0.5032 mL 2.5161 mL 5.0322 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 98.68%

SDS (252 KB)

COA (253 KB) HNMR (477 KB) RP-HPLC (259 KB) MS (69 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5161 mL 12.5805 mL 25.1610 mL 62.9026 mL
5 mM 0.5032 mL 2.5161 mL 5.0322 mL 12.5805 mL
10 mM 0.2516 mL 1.2581 mL 2.5161 mL 6.2903 mL
15 mM 0.1677 mL 0.8387 mL 1.6774 mL 4.1935 mL
20 mM 0.1258 mL 0.6290 mL 1.2581 mL 3.1451 mL
25 mM 0.1006 mL 0.5032 mL 1.0064 mL 2.5161 mL
30 mM 0.0839 mL 0.4194 mL 0.8387 mL 2.0968 mL
40 mM 0.0629 mL 0.3145 mL 0.6290 mL 1.5726 mL
50 mM 0.0503 mL 0.2516 mL 0.5032 mL 1.2581 mL
60 mM 0.0419 mL 0.2097 mL 0.4194 mL 1.0484 mL
80 mM 0.0315 mL 0.1573 mL 0.3145 mL 0.7863 mL
100 mM 0.0252 mL 0.1258 mL 0.2516 mL 0.6290 mL
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DN02 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DN023055009-00-9DN 02DN-02Epigenetic Reader DomainBRD8 bromodomain probeBRD9BRD4CBP/P300Inhibitorinhibitorinhibit

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