DSPE-PEG-Cy5 

DSPE-PEG-Cy5 is a fluorescent lipophilic PEG lipid. DSPE-PEG-Cy5 can insert into cell membranes and localize uniformly on them. DSPE-PEG-Cy5 can serve as a fluorescent model molecule to optimize and validate membrane insertion conditions for cell surface functionalization. DSPE-PEG-Cy5 can be used in research on drug delivery, cancer, and other fields^[1].

DSPE-PEG-Cy5 can be efficiently inserted into the cell membrane of CD47^KO B16F10 cells^[1].
DSPE-PEG-Cy5 shows high membrane modification efficiency, stable anchoring effect, and the strongest co-localization with cell membranes in HepG2 cells after incorporation into Lips600-Cy5^[2].
DSPE-PEG-Cy5 can be successfully anchored on the surface of ACDVs, with significant Cy5 fluorescence observed^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(C₂H₄O)_nC₇₆H₁₂₃N₄O₁₁P

2315262-02-1

O=C(NCCOCCOC(NCCO[P](OCC(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)([O-])=O)=O)CCCCCN(/C1=C/C=C/C=C\C(C(C)(C2=CC=CC=C32)C)=[N+]3C)C4=CC=CC=C4C1(C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Meng, H., et al. The programmable whole tumor cell vaccine with multiple immunogenicity enhancement strategies for high-efficiency antitumor immunotherapy. Sci. China Chem. 69, 484–495 (2026).

  [2]. Ma Y, et al. A High-Efficiency Bioorthogonal Tumor-Membrane Reactor for In Situ Selective and Sustained Prodrug Activation. Angew Chem Int Ed Engl. 2024;63(10):e202318372.  [Content Brief]

  [3]. Yang F, et al.Oral administration of DSPE-PEG-cholic acid-modified ACDVs loaded with siLIMA1 for anti-MASH therapy Cell Biomaterials, 2025; 1