Mg+ Indicator Probes

Mag-Fluo-4 AM, an analog of Fluo-4 AM (HY-101896), is an intracellular Mg²⁺ (K_d = 4.7 mM) indicator and a Ca²⁺ (K_d = 22 μM) indicator. Mag-Fluo-4 AM suitable for monitoring high concentrations and rapidly changing Ca²⁺ signals, and changes in intracellular Mg²⁺ homeostasis (Ex/Em = 496/525 nm).

KMG-104 is a cell-impermeant highly selective fluorescent Mg²⁺ probe. KMG-104 has been used widely and revealed Mg²⁺ mobilization in cytoplasm in various types of cells.

Calmagite is a chromomeric reagent which can be used to detect calcium and magnesium in various samples.

KMG-301AM TFA is the acetoxy methyl esterified form of KMG-301. KMG-301AM TFA successfully accumulates in mitochondria and then it is hydrolyzed to KMG-301. KMG-301 is an Mg²⁺-selective fluorescent probe functional in mitochondria in intact cells. Since the mitochondrial membrane is impermeable to KMG-301, it is not released upon depolarization of the mitochondrial membrane potential. KMG-301 can indicate changes in mitochondrial Mg2+ concentration and shows Mg²⁺ transport across the mitochondrial membrane in the early phases of a cellular model.

KMG-301AM is the acetoxy methyl esterified form of KMG-301. KMG-301AM successfully accumulates in mitochondria and then it is hydrolyzed to KMG-301. KMG-301 is an Mg²⁺-selective fluorescent probe functional in mitochondria in intact cells. Since the mitochondrial membrane is impermeable to KMG-301, it is not released upon depolarization of the mitochondrial membrane potential. KMG-301 can indicate changes in mitochondrial Mg2+ concentration and shows Mg²⁺ transport across the mitochondrial membrane in the early phases of a cellular model.

KMG-104AM is a Mg²⁺ fluorescent probe. KMG-104AM is a membrane-permeable ester-modified derivative of KMG-104, which serves as a reporter and imaging agent. KMG-104AM can track the increase in intracellular free magnesium ion concentration induced by mitochondrial uncoupling. KMG-104AM enables visualization of the three-dimensional distribution of intracellular magnesium ion concentration. KMG-104AM is applicable to research related to the functions of intracellular magnesium ions.

Mag-Indo-1 tetrapotassium salt is a cell impermeable fluorescent probe for Mg²⁺ detection.

Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions.

Mag-indo-1/AM is a cell-permeable fluorescent indicator for Mg²⁺ and also for Ca²⁺ (Ex=340-390 nm, Em=410-490 nm). Mag-indo-1/AM can be used to determine intracellular Mg²⁺ and Ca²⁺ concentrations.

Mag-Fura-2 tetrapotassium is a cell-impermeant UV excitable rational fluorescent Mg²⁺/Ca²⁺ indicator (Ex=334-360 nm, Em=510 nm). Mag-Fura-2 tetrapotassium can be used for the determination of Mg²⁺ and Ca²⁺ concentrations.

Ethyl benzo[6,7]-4-oxo-4H-quinolizine-3-carboxlate (Compound 3) is a Mg²⁺ selective fluorescent indicator.