2. Metabolic Enzyme/Protease
  3. ELOVL
  4. ELOVL6-IN-2

ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with an IC50 value of 34 nM.

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ELOVL6-IN-2

ELOVL6-IN-2 構造式

CAS 番号 : 1067647-43-1

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 89 在庫あり
Solution
10 mM * 1 mL in DMSO USD 89 在庫あり
Solid
5 mg $70 在庫あり
10 mg $120 在庫あり
25 mg $250 在庫あり
50 mg $365 在庫あり
100 mg $550 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 6 publication(s) in Google Scholar

ELOVL6-IN-2 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with an IC50 value of 34 nM[1].

IC50 & Target

IC50: 34 nM (ELOVL6)[1]
Cellular Effect
Cell Line Type Value Description References
COS-7 IC50
194 nM
Compound: 37
Inhibition of mouse ELOVL3 expressed in african green monkey COS7 cells
Inhibition of mouse ELOVL3 expressed in african green monkey COS7 cells
[PMID: 19388647]
COS-7 IC50
31 nM
Compound: 37
Inhibition of mouse ELOVL6 expressed in african green monkey COS7 cells
Inhibition of mouse ELOVL6 expressed in african green monkey COS7 cells
[PMID: 19388647]
COS-7 IC50
337 nM
Compound: 37
Inhibition of human ELOVL3 expressed in african green monkey COS7 cells assessed as stearoyl-CoA elongation
Inhibition of human ELOVL3 expressed in african green monkey COS7 cells assessed as stearoyl-CoA elongation
[PMID: 19388647]
COS-7 IC50
8.9 nM
Compound: 37
Inhibition of human ELOVL6 expressed in african green monkey COS7 cells assessed as palmitoyl-CoA elongation
Inhibition of human ELOVL6 expressed in african green monkey COS7 cells assessed as palmitoyl-CoA elongation
[PMID: 19388647]
COS-7 IC50
> 10 μM
Compound: 37
Inhibition of human ELOVL1 expressed in african green monkey COS7 cells
Inhibition of human ELOVL1 expressed in african green monkey COS7 cells
[PMID: 19388647]
COS-7 IC50
> 10 μM
Compound: 37
Inhibition of human ELOVL2 expressed in african green monkey COS7 cells
Inhibition of human ELOVL2 expressed in african green monkey COS7 cells
[PMID: 19388647]
COS-7 IC50
> 10 μM
Compound: 37
Inhibition of human ELOVL5 expressed in african green monkey COS7 cells
Inhibition of human ELOVL5 expressed in african green monkey COS7 cells
[PMID: 19388647]
体内実験

ELOVL6-IN-2 (0.1~1mg/kg; p.o.; 2 hours) potently and dose-proportionally suppresses the elongation index in the liver[1].
ELOVL6-IN-2 (10mg/kg; p.o.; 2 hours) demonstrates highly liver penetrable[1].
ELOVL6-IN-2 (1mg/kg; p.o.; 2~24 hours) exhibits sustained plasma exposure[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice
Dosage: 0.1~1mg/kg
Administration: P.o
Result: Potently and dose-proportionally suppressed the elongation index in the liver.
Animal Model: Male C57BL/6J mice
Dosage: 10 mg/kg
Administration: P.o
Result: Demonstrated highly liver penetrable.
Animal Model: Male C57BL/6J mice
Dosage: 1 mg/kg
Administration: P.o
Result: Exhibited sustained plasma exposure.
分子量

579.49

分子式

C28H23F6N3O4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=CC=C2)C3=C(C(CC(C)(C)C3)=O)C1(C4=C(C)NN(C5=CC=C(OC(F)(F)F)C=C5)C4=O)C(F)(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (172.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7257 mL 8.6283 mL 17.2566 mL
5 mM 0.3451 mL 1.7257 mL 3.4513 mL
10 mM 0.1726 mL 0.8628 mL 1.7257 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (4.31 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.31 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.91%

COA (254 KB) HNMR (277 KB) LCMS (267 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7257 mL 8.6283 mL 17.2566 mL 43.1414 mL
5 mM 0.3451 mL 1.7257 mL 3.4513 mL 8.6283 mL
10 mM 0.1726 mL 0.8628 mL 1.7257 mL 4.3141 mL
15 mM 0.1150 mL 0.5752 mL 1.1504 mL 2.8761 mL
20 mM 0.0863 mL 0.4314 mL 0.8628 mL 2.1571 mL
25 mM 0.0690 mL 0.3451 mL 0.6903 mL 1.7257 mL
30 mM 0.0575 mL 0.2876 mL 0.5752 mL 1.4380 mL
40 mM 0.0431 mL 0.2157 mL 0.4314 mL 1.0785 mL
50 mM 0.0345 mL 0.1726 mL 0.3451 mL 0.8628 mL
60 mM 0.0288 mL 0.1438 mL 0.2876 mL 0.7190 mL
80 mM 0.0216 mL 0.1079 mL 0.2157 mL 0.5393 mL
100 mM 0.0173 mL 0.0863 mL 0.1726 mL 0.4314 mL
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ELOVL6-IN-2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELOVL6-IN-21067647-43-1ELOVLElongation of Very Long-chain Fatty AcidsElongasepotentorallyselectivedose-proportionallyplasmaliverInhibitorinhibitorinhibit

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製品名:
ELOVL6-IN-2
製品番号:
HY-12146
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