2. Cytoskeleton
  3. Dynamin Clathrin
  4. ES9-17

ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings.

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ES9-17

ES9-17 Chemische Struktur

CAS. Nr. : 55854-43-8

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Based on 1 publication(s) in Google Scholar

ES9-17 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE ES9-17

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Beschreibung

ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings[1][2].

IC50 & Target
In Vitro

ES9-17 (0-100 μM; 30 min) inhibits the uptake of the lipophilic styryl endocytic tracer dye (FM4-64), with an EC50 value of 13 μM[1].
ES9-17 (30 μM; 30 min) doesn’t deplete cellular ATP[1].
ES9-17 (30 μM; 30 min) also reduces the uptake of transferrin in HeLa cells[1].
ES9-17 targets to CHC and mediates transport of materials among organelles without causing cytoplasmic acidification[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ES9-17 Related Antibodies
Molekulargewicht

318.21

Formel

C10H8BrNO2S2
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(Br)S1)(NC2=CC=CC=C2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (392.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1426 mL 15.7129 mL 31.4258 mL
5 mM 0.6285 mL 3.1426 mL 6.2852 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.68%

SDS (393 KB)

COA (250 KB) HNMR (256 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1426 mL 15.7129 mL 31.4258 mL 78.5645 mL
5 mM 0.6285 mL 3.1426 mL 6.2852 mL 15.7129 mL
10 mM 0.3143 mL 1.5713 mL 3.1426 mL 7.8564 mL
15 mM 0.2095 mL 1.0475 mL 2.0951 mL 5.2376 mL
20 mM 0.1571 mL 0.7856 mL 1.5713 mL 3.9282 mL
25 mM 0.1257 mL 0.6285 mL 1.2570 mL 3.1426 mL
30 mM 0.1048 mL 0.5238 mL 1.0475 mL 2.6188 mL
40 mM 0.0786 mL 0.3928 mL 0.7856 mL 1.9641 mL
50 mM 0.0629 mL 0.3143 mL 0.6285 mL 1.5713 mL
60 mM 0.0524 mL 0.2619 mL 0.5238 mL 1.3094 mL
80 mM 0.0393 mL 0.1964 mL 0.3928 mL 0.9821 mL
100 mM 0.0314 mL 0.1571 mL 0.3143 mL 0.7856 mL
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ES9-17 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ES9-1755854-43-8DynaminClathrinInhibitorinhibitorinhibit

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