55854-43-8
55854-43-8
Chemical Structure
ES9-17
- CAS No.: 55854-43-8
- Formula:C10H8BrNO2S2
- Molecular Weight:318.21
IUPAC Name: 5-bromo-N-phenylthiophene-2-sulfonamide
InChIKey: AIZXCKZVUXCHAP-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(Br)S1)(NC2=CC=CC=C2)=O
Biological Activity: ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ES9-17 | 99.68% | ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings. | ||||||||||||||||||||
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References
- [1]. Dejonghe W, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol. 2019 Jun;15(6):641-649. [Content Brief]
- [2]. Huang L, et al. Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking. Curr Opin Plant Biol. 2019 Dec;52:106-113. [Content Brief]
