ES9-17
Based on 1 publication(s) in Google Scholar
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings.
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- Purity: 99.68%
- CAS No.: 55854-43-8
- 화학식: C10H8BrNO2S2
- 분자량:318.21
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) ES9-17
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Biological Activity
ES9-17 (0-100 μM; 30 min) inhibits the uptake of the lipophilic styryl endocytic tracer dye (FM4-64), with an EC50 value of 13 μM[1].
ES9-17 (30 μM; 30 min) doesn’t deplete cellular ATP[1].
ES9-17 (30 μM; 30 min) also reduces the uptake of transferrin in HeLa cells[1].
ES9-17 targets to CHC and mediates transport of materials among organelles without causing cytoplasmic acidification[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 55854-43-8
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Appearance Solid
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분자량 318.21
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화학식 C10H8BrNO2S2
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Color White to off-white
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SMILES
O=S(C1=CC=C(Br)S1)(NC2=CC=CC=C2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
2024 Apr 23;15(1):3437. PMID: 38653755
용액&용해도
DMSO : 125 mg/mL (392.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Dejonghe W, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol. 2019 Jun;15(6):641-649. [Content Brief]
[2]. Huang L, et al. Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking. Curr Opin Plant Biol. 2019 Dec;52:106-113. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1426 mL | 15.7129 mL | 31.4258 mL | 78.5645 mL |
| 5 mM | 0.6285 mL | 3.1426 mL | 6.2852 mL | 15.7129 mL | |
| 10 mM | 0.3143 mL | 1.5713 mL | 3.1426 mL | 7.8564 mL | |
| 15 mM | 0.2095 mL | 1.0475 mL | 2.0951 mL | 5.2376 mL | |
| 20 mM | 0.1571 mL | 0.7856 mL | 1.5713 mL | 3.9282 mL | |
| 25 mM | 0.1257 mL | 0.6285 mL | 1.2570 mL | 3.1426 mL | |
| 30 mM | 0.1048 mL | 0.5238 mL | 1.0475 mL | 2.6188 mL | |
| 40 mM | 0.0786 mL | 0.3928 mL | 0.7856 mL | 1.9641 mL | |
| 50 mM | 0.0629 mL | 0.3143 mL | 0.6285 mL | 1.5713 mL | |
| 60 mM | 0.0524 mL | 0.2619 mL | 0.5238 mL | 1.3094 mL | |
| 80 mM | 0.0393 mL | 0.1964 mL | 0.3928 mL | 0.9821 mL | |
| 100 mM | 0.0314 mL | 0.1571 mL | 0.3143 mL | 0.7856 mL |
ES9-17 Related Classifications
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