FBPase-1 inhibitor-1

Name: FBPase-1 inhibitor-1
Brand: MedChemExpress
SKU: HY-136717
Rating: 4.5 (0 reviews)

Cat. No.: HY-136717 Purity: 98.54%: Data Sheet
COA

SDS
Handling Instructions
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FBPase-1 inhibitor-1 (Compound 1) is an allosteric FBPase-1 inhibitor with an IC₅₀ of 3.3 μM or 3.9 μM. FBPase-1 inhibitor-1 blocks gluconeogenesis by inhibiting FBPase-1. FBPase-1 inhibitor-1 can be used for the research of type 2 diabetes (t2dm).

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FBPase-1 inhibitor-1 화학구조

CAS No. : 883973-99-7

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[1]

FBPase-1

3.3 or 3.9 μM (IC₅₀)

In Vitro

FBPase-1 inhibitor-1 (10⁻⁸ to 10⁻³ M; duration of the enzymatic reaction) potently inhibits human FBPase-1 activity in the malachite green assay with an IC₅₀ of 3.3 ± 0.6 μM^[1].
FBPase-1 inhibitor-1 (10⁻⁸ to 10⁻³ M; duration of the enzymatic reaction) inhibits human FBPase-1 activity in the coupled enzyme assay with an IC₅₀ of 3.9 ± 0.6 μM and a K_i of 1.1 ± 0.1 μM^[1].
FBPase-1 inhibitor-1 (0.01-100 μM; 3 hours) blocks gluconeogenesis in H4IIE rat hepatoma cells by inhibiting FBPase-1, reducing glucose output with an IC₅₀ of 6.6 ± 1.6 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

377.63

화학식

C₁₃H₇Cl₃N₂O₃S

CAS No.

883973-99-7

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC(Cl)=CC=C1Cl)(NC2=NC3=CC(Cl)=CC=C3O2)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도

In Vitro:

DMSO : 125 mg/mL (331.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6481 mL	13.2405 mL	26.4809 mL
5 mM	0.5296 mL	2.6481 mL	5.2962 mL
10 mM	0.2648 mL	1.3240 mL	2.6481 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.54%

Select Batch:

Data Sheet (273 KB) SDS (394 KB)

COA (250 KB) RP-HPLC (226 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. von Geldern TW, et al. Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. Bioorg Med Chem Lett. 2006;16(7):1811-1815. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6481 mL	13.2405 mL	26.4809 mL	66.2024 mL
	5 mM	0.5296 mL	2.6481 mL	5.2962 mL	13.2405 mL
	10 mM	0.2648 mL	1.3240 mL	2.6481 mL	6.6202 mL
	15 mM	0.1765 mL	0.8827 mL	1.7654 mL	4.4135 mL
	20 mM	0.1324 mL	0.6620 mL	1.3240 mL	3.3101 mL
	25 mM	0.1059 mL	0.5296 mL	1.0592 mL	2.6481 mL
	30 mM	0.0883 mL	0.4413 mL	0.8827 mL	2.2067 mL
	40 mM	0.0662 mL	0.3310 mL	0.6620 mL	1.6551 mL
	50 mM	0.0530 mL	0.2648 mL	0.5296 mL	1.3240 mL
	60 mM	0.0441 mL	0.2207 mL	0.4413 mL	1.1034 mL
	80 mM	0.0331 mL	0.1655 mL	0.3310 mL	0.8275 mL
	100 mM	0.0265 mL	0.1324 mL	0.2648 mL	0.6620 mL