FBPase-1 inhibitor-1

Name: FBPase-1 inhibitor-1
Brand: MedChemExpress
SKU: HY-136717
Rating: 4.5 (0 reviews)

製品番号: HY-136717 純度: 98.54%: Data Sheet SDS COA 取扱説明書
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FBPase-1 inhibitor-1 (Compound 1) is an allosteric FBPase-1 inhibitor with an IC₅₀ of 3.3 μM or 3.9 μM. FBPase-1 inhibitor-1 blocks gluconeogenesis by inhibiting FBPase-1. FBPase-1 inhibitor-1 can be used for the research of type 2 diabetes (t2dm).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

FBPase-1 inhibitor-1 構造式

CAS 番号 : 883973-99-7

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 72	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 72	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$66	在庫あり	Estimated Time of Arrival: December 31
10 mg	$106	在庫あり	Estimated Time of Arrival: December 31
25 mg	$211	在庫あり	Estimated Time of Arrival: December 31
50 mg	$338	在庫あり	Estimated Time of Arrival: December 31
100 mg	$540	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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Based on 0 publication(s) in Google Scholar

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参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

FBPase-1

3.3 or 3.9 μM (IC₅₀)

体外実験

FBPase-1 inhibitor-1 (10⁻⁸ to 10⁻³ M; duration of the enzymatic reaction) potently inhibits human FBPase-1 activity in the malachite green assay with an IC₅₀ of 3.3 ± 0.6 μM^[1].
FBPase-1 inhibitor-1 (10⁻⁸ to 10⁻³ M; duration of the enzymatic reaction) inhibits human FBPase-1 activity in the coupled enzyme assay with an IC₅₀ of 3.9 ± 0.6 μM and a K_i of 1.1 ± 0.1 μM^[1].
FBPase-1 inhibitor-1 (0.01-100 μM; 3 hours) blocks gluconeogenesis in H4IIE rat hepatoma cells by inhibiting FBPase-1, reducing glucose output with an IC₅₀ of 6.6 ± 1.6 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

377.63

分子式

C₁₃H₇Cl₃N₂O₃S

CAS 番号

883973-99-7

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC(Cl)=CC=C1Cl)(NC2=NC3=CC(Cl)=CC=C3O2)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (331.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6481 mL	13.2405 mL	26.4809 mL
5 mM	0.5296 mL	2.6481 mL	5.2962 mL
10 mM	0.2648 mL	1.3240 mL	2.6481 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

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体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.54%

Select Batch:

データシート (273 KB) SDS (394 KB)

COA (250 KB) RP-HPLC (226 KB) MS (70 KB)

取扱説明書 (2659 KB)

参考文献

[1]. von Geldern TW, et al. Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. Bioorg Med Chem Lett. 2006;16(7):1811-1815. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6481 mL	13.2405 mL	26.4809 mL	66.2024 mL
	5 mM	0.5296 mL	2.6481 mL	5.2962 mL	13.2405 mL
	10 mM	0.2648 mL	1.3240 mL	2.6481 mL	6.6202 mL
	15 mM	0.1765 mL	0.8827 mL	1.7654 mL	4.4135 mL
	20 mM	0.1324 mL	0.6620 mL	1.3240 mL	3.3101 mL
	25 mM	0.1059 mL	0.5296 mL	1.0592 mL	2.6481 mL
	30 mM	0.0883 mL	0.4413 mL	0.8827 mL	2.2067 mL
	40 mM	0.0662 mL	0.3310 mL	0.6620 mL	1.6551 mL
	50 mM	0.0530 mL	0.2648 mL	0.5296 mL	1.3240 mL
	60 mM	0.0441 mL	0.2207 mL	0.4413 mL	1.1034 mL
	80 mM	0.0331 mL	0.1655 mL	0.3310 mL	0.8275 mL
	100 mM	0.0265 mL	0.1324 mL	0.2648 mL	0.6620 mL