2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGL peptide

FGL peptide is a fibroblast growth factor receptor (FGFR) modulator and blood-brain barrier-penetrant. FGL peptide activates NCAM-FGFR and FGFR1 signaling pathways. FGL peptide alters expression of apoptosis, signal transduction and metabolism regulator genes in traumatic brain injury contexts. FGL peptide can be used for the research of traumatic brain injury.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

FGL peptide

FGL peptide 화학구조

CAS No. : 499993-62-3

사이즈 가격 재고 수량
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

FGL peptide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

FGL peptide is a fibroblast growth factor receptor (FGFR) modulator and blood-brain barrier-penetrant. FGL peptide activates NCAM-FGFR and FGFR1 signaling pathways. FGL peptide alters expression of apoptosis, signal transduction and metabolism regulator genes in traumatic brain injury contexts. FGL peptide can be used for the research of traumatic brain injury[1][2].

In Vivo

FGL peptide (10 mg/kg; s.c.; every third day) modulates global gene expression in both injured and non-injured adolescent male Wistar rats, with effects supporting neuroprotection, reduced degeneration, and enhanced cellular stability and regenerative processes[1].
FGL peptide (2.6-26.0 µg; i.n.; on PND1, 2, and 3) accelerates maturation of vestibular-dependent sensorimotor coordination skills in newborn Wistar rats, specifically reducing surface righting reflex latency and increasing successful negative geotaxis responses on PND4-6, without affecting general motor activity, muscle strength, or body weight[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, adolescent, 100 g, traumatic brain injury model via dry ice application to skull)[1]
Dosage: 10 mg/kg
Administration: s.c.; every third day
Result: Altered the expression of 82 genes via interaction with TBI in injured animals. Upregulated a gene cluster including Fas apoptotic inhibitory molecule, regulator of G-protein signaling 14, and solute carrier family 7 member 1 at 4 days post-injury. Modulated expression of genes involved in metabolism, transcription, and cytoskeleton maintenance, with some genes showing upregulation at 6 hours and 4 days but downregulation at 1 day post-injury. Upregulated genes encoding neurofilament, adenylate cyclase activating polypeptide 1, and RNA binding protein p45AUF1 in non-injured animals. Downregulated genes encoding RNA helicase II, mitochondrial ribosomal protein 9, and metaxin 2 in non-injured animals.
분자량

1649.80

화학식

C71H116N20O25
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Glu-Val-Tyr-Val-Val-Ala-Glu-Asn-Gln-Gln-Gly-Lys-Ser-Lys-Ala
Sequence Shortening

EVYVVAENQQGKSKA
선적

Room temperature in continental US; may vary elsewhere.
보관

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도
In Vitro: 

H2O : ≥ 100 mg/mL (60.61 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6061 mL 3.0307 mL 6.0613 mL
5 mM 0.1212 mL 0.6061 mL 1.2123 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6061 mL 3.0307 mL 6.0613 mL 15.1534 mL
5 mM 0.1212 mL 0.6061 mL 1.2123 mL 3.0307 mL
10 mM 0.0606 mL 0.3031 mL 0.6061 mL 1.5153 mL
15 mM 0.0404 mL 0.2020 mL 0.4041 mL 1.0102 mL
20 mM 0.0303 mL 0.1515 mL 0.3031 mL 0.7577 mL
25 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.6061 mL
30 mM 0.0202 mL 0.1010 mL 0.2020 mL 0.5051 mL
40 mM 0.0152 mL 0.0758 mL 0.1515 mL 0.3788 mL
50 mM 0.0121 mL 0.0606 mL 0.1212 mL 0.3031 mL
60 mM 0.0101 mL 0.0505 mL 0.1010 mL 0.2526 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

FGL peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGL peptide499993-62-3FGFRFibroblast growth factor receptortraumatic brain injuryblood-brain barriernewborn ratsNCAM-FGFRadult ratsfibroblast growth factor receptorWistar ratsFGFR1 signaling pathwayscerebrospinal fluidInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
FGL peptide
Cat. No.:
HY-P3281
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.