Flavagline FL3

製品番号: HY-123554 純度: 99.90%: Data Sheet SDS COA 取扱説明書
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Flavagline FL3 is a flavagline with potent and selective cytotoxicity in cancer cells.Flavagline FL3 induces apoptosis of HL60 and Hela cells by triggering the translocation of Apoptosis Inducing Factor (AIF) and caspase-12 to the nucleus.

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Flavagline FL3 構造式

CAS 番号 : 1186012-80-5

容量	価格（税別）	在庫状況	数量
5 mg	$991	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1586	在庫あり	Estimated Time of Arrival: December 31
25 mg	$2855	在庫あり	Estimated Time of Arrival: December 31
50 mg	$4564	在庫あり	Estimated Time of Arrival: December 31
100 mg	$6846	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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Based on 0 publication(s) in Google Scholar

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製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	< 1 1 Compound: 3	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 19655762]
HCT-15	IC₅₀	1 1 Compound: 3	Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay	[PMID: 19655762]
HCT-116	IC₅₀	5.8 1 Compound: 2, FL3	Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
MCF7	IC₅₀	1 1 Compound: 3	Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 19655762]
HCT-116	IC₅₀	7.6 1 Compound: 1a	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 21142180]
KB	IC₅₀	2.4 1 Compound: 2, FL3	Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
HL-60	IC₅₀	3.8 1 Compound: 2, FL3	Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
HCT-15	IC₅₀	1 1 Compound: 3	Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay	[PMID: 19655762]
MDA-MB-231	IC₅₀	3.8 1 Compound: 1a	Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay	[PMID: 21142180]
HCT-116	IC₅₀	5.8 1 Compound: 2, FL3	Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
HepG2	IC₅₀	4 1 Compound: 3	Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay	[PMID: 19655762]
HepG2	IC₅₀	4 1 Compound: 3	Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay	[PMID: 19655762]
HCT-116	IC₅₀	7.6 1 Compound: 1a	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	< 1 1 Compound: 3	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 19655762]
HL-60	IC₅₀	3.8 1 Compound: 2, FL3	Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
HCT-116	IC₅₀	< 1 1 Compound: 3	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 19655762]
HL-60	IC₅₀	4.5 1 Compound: 1a	Cytotoxicity against human HL60R cells after 72 hrs by MTS assay Cytotoxicity against human HL60R cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	4.5 1 Compound: 1a	Cytotoxicity against human HL60R cells after 72 hrs by MTS assay Cytotoxicity against human HL60R cells after 72 hrs by MTS assay	[PMID: 21142180]
HCT-15	IC₅₀	1 1 Compound: 3	Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay	[PMID: 19655762]
HL-60	IC₅₀	5.5 1 Compound: 1a	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	5.5 1 Compound: 1a	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 21142180]
HCT-116	IC₅₀	5.8 1 Compound: 2, FL3	Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
HEK-293T	IC₅₀	22.4 1 Compound: FL3	Antiviral activity against CHIKV infected in HEK293T cells Antiviral activity against CHIKV infected in HEK293T cells	[PMID: 38394369]
HL-60	IC₅₀	3.8 1 Compound: 2, FL3	Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HL60 cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
HCT-116	IC₅₀	7.6 1 Compound: 1a	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 21142180]
KB	IC₅₀	< 1 1 Compound: 3	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 19655762]
KB	IC₅₀	15 1 Compound: 1a	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	4.5 1 Compound: 1a	Cytotoxicity against human HL60R cells after 72 hrs by MTS assay Cytotoxicity against human HL60R cells after 72 hrs by MTS assay	[PMID: 21142180]
SK-OV-3	IC₅₀	8.5 1 Compound: 1a	Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay	[PMID: 21142180]
KB	IC₅₀	2.4 1 Compound: 2, FL3	Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
MDA-MB-435	IC₅₀	8.7 1 Compound: 1a	Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	5.5 1 Compound: 1a	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	< 1 1 Compound: 3	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 19655762]
SW48	IC₅₀	10 1 Compound: 154; FL3	Anticancer activity against human SW48 cells assessed as cell growth inhibition Anticancer activity against human SW48 cells assessed as cell growth inhibition	[PMID: 33445154]
MCF7	IC₅₀	< 1 1 Compound: 3	Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay	[PMID: 19655762]
MCF7	IC₅₀	1 1 Compound: 3	Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 19655762]
KB	IC₅₀	15 1 Compound: 1a	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 21142180]
HepG2	IC₅₀	4 1 Compound: 3	Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay	[PMID: 19655762]
MDA-MB-231	IC₅₀	3.8 1 Compound: 1a	Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay	[PMID: 21142180]
KB	IC₅₀	15 1 Compound: 1a	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 21142180]
PC-3	IC₅₀	17 1 Compound: 1a	Cytotoxicity against human PC3 cells after 72 hrs by MTS assay Cytotoxicity against human PC3 cells after 72 hrs by MTS assay	[PMID: 21142180]
MDA-MB-435	IC₅₀	8.7 1 Compound: 1a	Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay	[PMID: 21142180]
HEK-293T	IC₅₀	22.4 1 Compound: FL3	Antiviral activity against CHIKV infected in HEK293T cells Antiviral activity against CHIKV infected in HEK293T cells	[PMID: 38394369]
KB	IC₅₀	2.4 1 Compound: 2, FL3	Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay	[PMID: 23072299]
KB	IC₅₀	< 1 1 Compound: 3	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 19655762]
PC-3	IC₅₀	17 1 Compound: 1a	Cytotoxicity against human PC3 cells after 72 hrs by MTS assay Cytotoxicity against human PC3 cells after 72 hrs by MTS assay	[PMID: 21142180]
HCT-116	IC₅₀	<1 1 Compound: 3	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 19655762]
MCF7	IC₅₀	1 1 Compound: 3	Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 19655762]
SK-OV-3	IC₅₀	8.5 1 Compound: 1a	Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay	[PMID: 21142180]
HL-60	IC₅₀	<1 1 Compound: 3	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 19655762]
MCF7	IC₅₀	< 1 1 Compound: 3	Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay	[PMID: 19655762]
KB	IC₅₀	<1 1 Compound: 3	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 19655762]
MDA-MB-231	IC₅₀	3.8 1 Compound: 1a	Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay Cytotoxicity against human MDA231 cells after 72 hrs by MTS assay	[PMID: 21142180]
MCF7	IC₅₀	<1 1 Compound: 3	Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay	[PMID: 19655762]
MDA-MB-435	IC₅₀	8.7 1 Compound: 1a	Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay Cytotoxicity against human MDA435 cells after 72 hrs by MTS assay	[PMID: 21142180]
PC-3	IC₅₀	17 1 Compound: 1a	Cytotoxicity against human PC3 cells after 72 hrs by MTS assay Cytotoxicity against human PC3 cells after 72 hrs by MTS assay	[PMID: 21142180]
SK-OV-3	IC₅₀	8.5 1 Compound: 1a	Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay	[PMID: 21142180]
SW48	IC₅₀	10 1 Compound: 154; FL3	Anticancer activity against human SW48 cells assessed as cell growth inhibition Anticancer activity against human SW48 cells assessed as cell growth inhibition	[PMID: 33445154]

分子量

483.35

分子式

C₂₅H₂₃BrO₅

CAS 番号

1186012-80-5

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1C[C@H]([C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]21O)C4=CC=C(C=C4)Br)C5=CC=CC=C5

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (206.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0689 mL	10.3445 mL	20.6889 mL
5 mM	0.4138 mL	2.0689 mL	4.1378 mL
10 mM	0.2069 mL	1.0344 mL	2.0689 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.90%

Select Batch:

データシート (277 KB) SDS (251 KB)

COA (262 KB) HNMR (279 KB) RP-HPLC (231 KB) LCMS (110 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Frédéric Thuaud, et al. Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12. J Med Chem. 2009 Aug 27;52(16):5176-87. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0689 mL	10.3445 mL	20.6889 mL	51.7224 mL
	5 mM	0.4138 mL	2.0689 mL	4.1378 mL	10.3445 mL
	10 mM	0.2069 mL	1.0344 mL	2.0689 mL	5.1722 mL
	15 mM	0.1379 mL	0.6896 mL	1.3793 mL	3.4482 mL
	20 mM	0.1034 mL	0.5172 mL	1.0344 mL	2.5861 mL
	25 mM	0.0828 mL	0.4138 mL	0.8276 mL	2.0689 mL
	30 mM	0.0690 mL	0.3448 mL	0.6896 mL	1.7241 mL
	40 mM	0.0517 mL	0.2586 mL	0.5172 mL	1.2931 mL
	50 mM	0.0414 mL	0.2069 mL	0.4138 mL	1.0344 mL
	60 mM	0.0345 mL	0.1724 mL	0.3448 mL	0.8620 mL
	80 mM	0.0259 mL	0.1293 mL	0.2586 mL	0.6465 mL
	100 mM	0.0207 mL	0.1034 mL	0.2069 mL	0.5172 mL

Flavagline FL3 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flavagline FL31186012-80-5Flavagline FL 3Flavagline FL-3ApoptosiscytotoxicityapoptosisAIFcaspase-12Inhibitorinhibitorinhibit

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Flavagline FL3

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Flavagline FL3 関連抗体

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Flavagline FL3 Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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