2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Aryl Hydrocarbon Receptor Drug Metabolite
  4. Foscarbidopa

Foscarbidopa  (Synonyms: ABBV-951; Carbidopa 4′-monophosphate)

Cat. No.: HY-109131 Purity: 95.91%
COA
SDS
Handling Instructions Technical Support

Foscarbidopa (ABBV-951; Carbidopa 4′-monophosphate) is an inhibitory prodrug targeting peripheral aromatic L-amino acid decarboxylase. Foscarbidopa is hydrolyzed into Carbidopa (HY-B0311) by phosphatases in vivo to suppress peripheral metabolism of levodopa and elevate brain delivery of levodopa. Foscarbidopa can be used for the research of Parkinson’s disease and advanced Parkinson’s disease.

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Foscarbidopa

Foscarbidopa 화학구조

CAS No. : 1907685-81-7

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in Water 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Foscarbidopa Related Antibodies

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제품 설명

Foscarbidopa (ABBV-951; Carbidopa 4′-monophosphate) is an inhibitory prodrug targeting peripheral aromatic L-amino acid decarboxylase. Foscarbidopa is hydrolyzed into Carbidopa (HY-B0311) by phosphatases in vivo to suppress peripheral metabolism of levodopa and elevate brain delivery of levodopa. Foscarbidopa can be used for the research of Parkinson’s disease and advanced Parkinson’s disease[1][2].

IC50 & Target

dopamine receptor[2]
In Vivo

Foscarbidopa (formulated with foslevodopa; 4:1 ratio; continuous subcutaneous infusion) provides effective levodopa concentrations in rats for Parkinson’s disease research[1].
Foscarbidopa (combined with foslevodopa; intravenous/subcutaneous bolus/infusion) shows favorable pharmacokinetic profiles in rats, dogs, Göttingen minipigs and monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
분자량

306.21

화학식

C10H15N2O7P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O)OC(C=CC(C[C@@](NN)(C)C(O)=O)=C1)=C1O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

H2O : 10 mg/mL (32.66 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2657 mL 16.3287 mL 32.6573 mL
5 mM 0.6531 mL 3.2657 mL 6.5315 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2657 mL 16.3287 mL 32.6573 mL 81.6433 mL
5 mM 0.6531 mL 3.2657 mL 6.5315 mL 16.3287 mL
10 mM 0.3266 mL 1.6329 mL 3.2657 mL 8.1643 mL
15 mM 0.2177 mL 1.0886 mL 2.1772 mL 5.4429 mL
20 mM 0.1633 mL 0.8164 mL 1.6329 mL 4.0822 mL
25 mM 0.1306 mL 0.6531 mL 1.3063 mL 3.2657 mL
30 mM 0.1089 mL 0.5443 mL 1.0886 mL 2.7214 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Foscarbidopa Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Foscarbidopa1907685-81-7ABBV-951 Carbidopa 4′-monophosphateABBV951ABBV 951Aryl Hydrocarbon ReceptorDrug MetaboliteAhRperipheral dopa decarboxylaseParkinson’s diseaseadvanced Parkinson’s diseasecarbidopaInhibitorinhibitorinhibit

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상품명:
Foscarbidopa
Cat. No.:
HY-109131
수량:
MCE Japan Authorized Agent:

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