Galectin-3-IN-4 

Galectin-3-IN-4 (compound 5) is a carboxamide analog. Galectin-3-IN-4 is a potent, selective, and orally bioavailable inhibitor of human and mouse galectin-3, with IC₅₀ values of 21 and 167 nM for hGal-3 and mGal-3, respectively. Galectin-3-IN-4 has IC₅₀ values of 1580 and 2750 nM for hGal-1 and hGal-9, respectively^[1].

Galectin-3-IN-4 (compound 5) (2 mg/kg IV, 10 mg/kg PO; once) has a low clearance rate (CL = 12 mL/min/kg) and a high volume of distribution (Vss = 2.1 L/kg), and has a 52 % oral bioavailabilities in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

565.98

C₂₄H₂₂ClF₂N₅O₅S

2496515-38-7

CO[C@@H]1[C@@H](N2C=C(C3=C(C(F)=C(C=C3)Cl)F)N=N2)[C@H]([C@H](O[C@H]1C(N(C4=CC=C(N=CS5)C5=C4)C)=O)CO)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024 Mar 1;101:117638.  [Content Brief]