Ripk3 - receptor-interacting serine-threonine kinase 3 Gene

Also Known as Rip3; Hcyp2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246240

About Ripk3

Primary_assembly 15: 29,283,145-29,292,121 reverse strand.mRatBN7.2:CM026988.1

This gene has 3 transcripts (splice variants), 245 orthologues, 23 paralogues and is associated with 31 phenotypes. Biased expression in Spleen (RPKM 11.3), Thymus (RPKM 69.4) and 7 other tissues.

Summary

Predicted to enable NF-kappaB-inducing kinase activity; identical protein binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including hematopoietic or lymphoid organ development; necroptotic process; and positive regulation of phosphate metabolic process. Predicted to act upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of protein deacetylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ripk3 Products (1)

mRNA Protein Name
NM_139342.2 NP_647558.2 receptor-interacting serine/threonine-protein kinase 3

Ripk3 Protein Structure

PKc_like

PKc_like: cl21453 (27 - 284)

RHIM

RHIM: pfam12721 (412 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 478 a.a.
Protein Preferred Names Protein Names

receptor-interacting serine/threonine-protein kinase 3

  • RIP-3

  • RIP-like protein kinase 3

  • homocysteine respondent protein HCYP2

  • receptor-interacting protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101872 GSK-872 Inhibitor 99.91% Unkown
HY-101872A GSK-872 hydrochloride Inhibitor 98.85% Unkown
HY-158312 UH15-38 Inhibitor 99.80% Unkown
HY-104021 GSK840 Inhibitor 99.95% Unkown
HY-125402 GSK-843 Inhibitor 99.53% Unkown
HY-N2909 Aurantiamide Inhibitor 99.56% Unkown
HY-N0546 Ligustroflavone Inhibitor 99.90% Unkown
HY-131064 RIPK3-IN-1 Inhibitor 99.30% Unkown
HY-148365 NecroIr1 Activator 98.53% Unkown
HY-148366 NecroIr2 Activator 98.02% Unkown
HY-151873 SZM679 Inhibitor 99.59% Unkown
HY-183564 RIPK1/RIPK3-PPI-IN-1 Inhibitor / Unkown
HY-180806 RIPK1-IN-39 Inhibitor / Unkown
HY-173454 RIPK2/3-IN-2 Inhibitor 99.67% Unkown
HY-175026 RIPK2-IN-8 Inhibitor / Unkown
HY-171986 RIPK3-IN-6 Inhibitor 98.03% Unkown
HY-181596 WJH-C19 Inhibitor 98.65% Unkown
HY-178163 Zharp1-163 Inhibitor / Unkown
HY-184686 RIPK1-IN-42 Inhibitor / Unkown
HY-183339 IL-6/RIPK3-IN-1 Inhibitor / Unkown
HY-183538 Necroptosis inducer 2 Activator / Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-158312A UH15-38 TFA Inhibitor 99.77% Unkown
HY-184001 LT-1339-553 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ripk3 NCBI NCBI:11035