2. Gene
  3. Ripk3 - receptor-interacting serine-threonine kinase 3 Gene

Ripk3 - receptor-interacting serine-threonine kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Rip3; Hcyp2

Gene ID: 246240 | Gene type: protein coding

About Ripk3

Primary_assembly 15: 29,283,145-29,292,121 reverse strand.mRatBN7.2:CM026988.1

This gene has 3 transcripts (splice variants), 245 orthologues, 23 paralogues and is associated with 31 phenotypes. Biased expression in Spleen (RPKM 11.3), Thymus (RPKM 69.4) and 7 other tissues.

Summary

Predicted to enable NF-kappaB-inducing kinase activity; identical protein binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including hematopoietic or lymphoid organ development; necroptotic process; and positive regulation of phosphate metabolic process. Predicted to act upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of protein deacetylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ripk3 Products(1)

mRNA Protein Name
NM_139342.2 NP_647558.2 receptor-interacting serine/threonine-protein kinase 3

Ripk3 Protein Structure

PKc_like

PKc_like: cl21453 (27 - 284)

RHIM

RHIM: pfam12721 (412 - 456)

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  • 478 a.a.
Protein Preferred Names Protein Names

receptor-interacting serine/threonine-protein kinase 3

RIP-3

RIP-like protein kinase 3

homocysteine respondent protein HCYP2

receptor-interacting protein 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101872 GSK-872 Inhibitor 99.91% Unkown
HY-101872A GSK-872 hydrochloride Inhibitor 99.21% Unkown
HY-125402 GSK-843 Inhibitor 99.18% Unkown
HY-131064 RIPK3-IN-1 Inhibitor 99.19% Unkown
HY-148365 NecroIr1 Activator 98.02% Unkown
HY-148366 NecroIr2 Activator 98.99% Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-151873 SZM679 Inhibitor 99.59% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ripk3 NCBI NCBI:11035
Mus musculus Ripk3 NCBI NCBI:56532