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RIPK3 - receptor interacting serine/threonine kinase 3 Gene

Also Known as RIP3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11035

About RIPK3

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,336,025-24,339,991 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 245 orthologues and 23 paralogues. Broad expression in small intestine (RPKM 12.2), duodenum (RPKM 10.4) and 21 other tissues.

Summary

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from Other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce Apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

RIPK3 Products (1)

mRNA	Protein	Name
NM_006871.4	NP_006862.2	receptor-interacting serine/threonine-protein kinase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22817896	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19524512	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	22265413	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	22817896	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19524513	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	22265414	GOA
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	22265414	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	22817896	GOA
involved in amyloid fibril formation	IMP IMP: Inferred from mutant phenotype	22817896	GOA
involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	21737330	GOA
involved in necroptotic signaling pathway	IDA IDA: Inferred from direct assay	22265413	GOA
involved in necroptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	22265413	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	21931591	GOA
involved in positive regulation of necroptotic process	IDA IDA: Inferred from direct assay	22265414	GOA
involved in positive regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	22817896	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	22265413	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	30271893	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22817896	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIPK3 Protein Structure

Pkinase

RHIM

0
100
200
300
400
518 a.a.

Protein Preferred Names	Protein Names
receptor-interacting serine/threonine-protein kinase 3	RIP-3 RIP-like protein kinase 3 receptor interacting protein 3

RIPK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RIPK3	Q9Y572	MLKL	Homo sapiens	Q8NB16	Anti Tag CoIP	22265413
Intra	RIPK3	Q9Y572	MLKL	Homo sapiens	Q8NB16	Protein Kinase Assay	22265413
Intra	RIPK3	Q9Y572	MLKL	Homo sapiens	Q8NB16	Anti Tag CoIP	22265414
Cross	RIPK3	Q9Y572	ORF3a	Human SARS coronavirus	J9TC74	Confocal	30185776
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	19524512
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	22265414
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Pull Down	22817896
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	22265414
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	22817896
Intra	RIPK3	Q9Y572	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	22265413
Intra	RIPK3	Q9Y572	ZBP1	Homo sapiens	Q9H171	Anti Tag CoIP	19590578

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RIPK3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71855	RIPK3 Protein, Human (P.pastoris, His)	Q9Y572-1 (M1-K518)	≥ 90%, as determined by reducing SDS-PAGE.

RIPK3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810290	Phospho-RIP3 (S232) Antibody (YA9633)	WB	Mouse
HY-P810290A	Phospho-RIP3 (S232) Antibody (YA9633)(PBS only)	WB	Mouse
HY-P86351	RIP3 Antibody (YA6043)	WB, ICC/IF, IP, ELISA	Mouse

Related Diseases

Diseases	Alias
Caspase 8 Deficiency	Autoimmune Lymphoproliferative Syndrome Type 2b Ceds Alps2b Caspase-8 Deficiency Autoimmune Lymphoproliferative Syndrome, Type Iib Alps With Recurrent Viral Infections Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections Caspase 8 Deficiency Syndrome Autoimmune Lymphoproliferative Syndrome Type Iib Caspase Eight Deficiency State CASP8D
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Autoinflammation, Panniculitis, And Dermatosis Syndrome	Otulipenia Otulin-Related Autoinflammatory Syndrome AIPDS Oras Infantile-Onset Periodic Fever-Panniculitis-Dermatosis Syndrome Autoinflammation, Panniculitis And Dermatosis Syndrome Otulin Deficiency
Retinal Detachment	Retinal Detachments Rhegmatogenous Retinal Detachment Ruptured Retina With Detachment Retinal Hole With Detachment
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101872	GSK-872	Inhibitor	99.91%	Unkown
HY-101872A	GSK-872 hydrochloride	Inhibitor	98.85%	Unkown
HY-158312	UH15-38	Inhibitor	99.80%	Unkown
HY-104021	GSK840	Inhibitor	99.95%	Unkown
HY-125402	GSK-843	Inhibitor	99.53%	Unkown
HY-N2909	Aurantiamide	Inhibitor	99.56%	Unkown
HY-N0546	Ligustroflavone	Inhibitor	99.90%	Unkown
HY-131064	RIPK3-IN-1	Inhibitor	99.30%	Unkown
HY-148365	NecroIr1	Activator	98.53%	Unkown
HY-148366	NecroIr2	Activator	98.02%	Unkown
HY-151873	SZM679	Inhibitor	99.59%	Unkown
HY-183564	RIPK1/RIPK3-PPI-IN-1	Inhibitor	/	Unkown
HY-180806	RIPK1-IN-39	Inhibitor	/	Unkown
HY-173454	RIPK2/3-IN-2	Inhibitor	99.67%	Unkown
HY-175026	RIPK2-IN-8	Inhibitor	/	Unkown
HY-171986	RIPK3-IN-6	Inhibitor	98.03%	Unkown
HY-181596	WJH-C19	Inhibitor	98.65%	Unkown
HY-178163	Zharp1-163	Inhibitor	/	Unkown
HY-184686	RIPK1-IN-42	Inhibitor	/	Unkown
HY-183339	IL-6/RIPK3-IN-1	Inhibitor	/	Unkown
HY-183538	Necroptosis inducer 2	Activator	/	Unkown
HY-149052	SZM-1209	Inhibitor	/	Unkown
HY-158312A	UH15-38 TFA	Inhibitor	/	Unkown
HY-184001	LT-1339-553	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RIPK3	VGNC	VGNC:64642
Rattus norvegicus	RIPK3	RGD	RGD:628899
Mus musculus	RIPK3	MGD	MGI:2154952
Bos taurus	RIPK3	VGNC	VGNC:52818
Canis familiaris	RIPK3	VGNC	VGNC:110550
Others	RIPK3	NCBI