2. Apoptosis
  3. RIP kinase
  4. RIPK3-IN-6

RIPK3-IN-6 (compound 1) is a type I RIPK3 inhibitor with poor selectivity for the RIPK family, especially for RIPK2 activity.

For research use only. We do not sell to patients.

RIPK3-IN-6

RIPK3-IN-6 Chemical Structure

CAS No. : 955879-75-1

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Based on 1 publication(s) in Google Scholar

RIPK3-IN-6 Related Antibodies

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RIPK1 RIPK2 RIPK3

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Description

RIPK3-IN-6 (compound 1) is a type I RIPK3 inhibitor with poor selectivity for the RIPK family, especially for RIPK2 activity[1].

IC50 & Target

RIPK3

 

Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
75 nM
Compound: 33
Inhibition of RET kinase in Sf9 cells
Inhibition of RET kinase in Sf9 cells
[PMID: 17884497]
Molecular Weight

327.38

Formula

C21H17N3O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC=C(C)C(NC2=CC=NC3=CC(C4=NC=CC=C4)=CC=C23)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (95.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0546 mL 15.2728 mL 30.5455 mL
5 mM 0.6109 mL 3.0546 mL 6.1091 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0546 mL 15.2728 mL 30.5455 mL 76.3639 mL
5 mM 0.6109 mL 3.0546 mL 6.1091 mL 15.2728 mL
10 mM 0.3055 mL 1.5273 mL 3.0546 mL 7.6364 mL
15 mM 0.2036 mL 1.0182 mL 2.0364 mL 5.0909 mL
20 mM 0.1527 mL 0.7636 mL 1.5273 mL 3.8182 mL
25 mM 0.1222 mL 0.6109 mL 1.2218 mL 3.0546 mL
30 mM 0.1018 mL 0.5091 mL 1.0182 mL 2.5455 mL
40 mM 0.0764 mL 0.3818 mL 0.7636 mL 1.9091 mL
50 mM 0.0611 mL 0.3055 mL 0.6109 mL 1.5273 mL
60 mM 0.0509 mL 0.2545 mL 0.5091 mL 1.2727 mL
80 mM 0.0382 mL 0.1909 mL 0.3818 mL 0.9545 mL
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RIPK3-IN-6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIPK3-IN-6955879-75-1RIP kinaseReceptor-interacting protein kinasesRIPKInhibitorinhibitorinhibit

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HY-171986
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