2. Immunology/Inflammation Apoptosis Epigenetics
  3. Interleukin Related RIP kinase Epigenetic Reader Domain
  4. IL-6/RIPK3-IN-1

IL-6/RIPK3-IN-1 is an inhibitor of IL-6, RIPK3 and BRD4, with IC50 values of 0.22, 1.32 and 5.91 μM, respectively. IL-6/RIPK3-IN-1 can be used in studies related to inflammation and tissue damage.

For research use only. We do not sell to patients.

IL-6/RIPK3-IN-1

IL-6/RIPK3-IN-1 Chemical Structure

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IL-6/RIPK3-IN-1 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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RIPK1 RIPK2 RIPK3

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Description

IL-6/RIPK3-IN-1 is an inhibitor of IL-6, RIPK3 and BRD4, with IC50 values of 0.22, 1.32 and 5.91 μM, respectively. IL-6/RIPK3-IN-1 can be used in studies related to inflammation and tissue damage[1].

IC50 & Target[1]

IL-6

0.22 μM (IC50)

RIPK3

1.32 μM (IC50)

BRD4

5.91 μM (IC50)

In Vitro

IL-6/RIPK3-IN-1 (Compound 12m) exhibits moderate metabolic stability with a T1/2 of 33.2 min in human liver microsomes and 11.0 min in mouse liver microsomes, has solubility <1 μM at pH 7.4, and a log D of 4.1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IL-6/RIPK3-IN-1 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 AUClast CL_obs Tmax Cmax Bioavailability
Mice[1] 1 mg/kg i.v. 0.96 h 255 ng·h/mL 65.5 mL/min/kg / / /
Mice[1] 10 mg/kg p.o. 1.58 h 2432 ng·h/mL / 0.50 h 2127 ng/mL >90 %
Mice[1] 10 mg/kg s.c. 1.87 h 5013 ng·h/mL / 0.33 h 4683 ng/mL >90 %
Mice[1] 10 mg/kg i.p. 2.02 h 2513 ng·h/mL / 0.25 h 4573 ng/mL >90 %
Molecular Weight

378.40

Formula

C20H19FN6O
SMILES

FC(C=CC=C1)=C1N(C)C2=NC(NC3=CC(CN(C)C(N4)=O)=C4C=C3)=NC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IL-6/RIPK3-IN-1 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IL-6/RIPK3-IN-1Interleukin RelatedRIP kinaseEpigenetic Reader DomainILReceptor-interacting protein kinasesRIPKIL-6human liver microsomesmouse liver microsomesBRD4tissue injuryarsenical-induced inflammationRIPK3Inhibitorinhibitorinhibit

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