IL-6/RIPK3-IN-1
IL-6/RIPK3-IN-1 is an inhibitor of IL-6, RIPK3 and BRD4, with IC50 values of 0.22, 1.32 and 5.91 μM, respectively. IL-6/RIPK3-IN-1 can be used in studies related to inflammation and tissue damage.
For research use only. We do not sell to patients.
- Formula: C20H19FN6O
- Molecular Weight:378.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-6 0.22 μM (IC50) |
RIPK3 1.32 μM (IC50) |
BRD4 5.91 μM (IC50) |
IL-6/RIPK3-IN-1 (Compound 12m) exhibits moderate metabolic stability with a T1/2 of 33.2 min in human liver microsomes and 11.0 min in mouse liver microsomes, has solubility <1 μM at pH 7.4, and a log D of 4.1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | AUClast | CL_obs | Tmax | Cmax | Bioavailability |
|---|---|---|---|---|---|---|---|---|
| Mice[1] | 1 mg/kg | i.v. | 0.96 h | 255 ng·h/mL | 65.5 mL/min/kg | / | / | / |
| Mice[1] | 10 mg/kg | p.o. | 1.58 h | 2432 ng·h/mL | / | 0.50 h | 2127 ng/mL | >90 % |
| Mice[1] | 10 mg/kg | s.c. | 1.87 h | 5013 ng·h/mL | / | 0.33 h | 4683 ng/mL | >90 % |
| Mice[1] | 10 mg/kg | i.p. | 2.02 h | 2513 ng·h/mL | / | 0.25 h | 4573 ng/mL | >90 % |
Chemical Information
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Molecular Weight 378.40
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Formula C20H19FN6O
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SMILES
FC(C=CC=C1)=C1N(C)C2=NC(NC3=CC(CN(C)C(N4)=O)=C4C=C3)=NC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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