Ripk3 - receptor-interacting serine-threonine kinase 3 Gene

Also Known as Rip3; 2610528K09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56532

About Ripk3

Chromosome 14: 56,022,452-56,026,322 reverse strand.GRCm39:CM001007.3

This gene has 9 transcripts (splice variants), 245 orthologues, 23 paralogues and is associated with 11 phenotypes. Broad expression in large intestine adult (RPKM 17.7), thymus adult (RPKM 1.3) and 18 other tissues.

Summary

Enables NF-kappaB-inducing kinase activity and protein serine/threonine kinase activity. Involved in several processes, including execution phase of necroptosis; hematopoietic or lymphoid organ development; and regulation of programmed cell death. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of protein deacetylation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; male reproductive gland or organ; primitive streak; and turbinate bone primordium. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ripk3 Products (3)

mRNA Protein Name
NM_001164108.1 NP_001157580.1 receptor-interacting serine/threonine-protein kinase 3 isoform 2
NM_001164107.1 NP_001157579.1 receptor-interacting serine/threonine-protein kinase 3 isoform 2
NM_019955.2 NP_064339.2 receptor-interacting serine/threonine-protein kinase 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19498109 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
10490590 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
24012422 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell differentiation in thymus IGI
IGI: Inferred from genetic interaction
21876153 MGI
involved in T cell homeostasis IGI
IGI: Inferred from genetic interaction
21876153 MGI
involved in cellular response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
27258785 MGI
involved in defense response to virus IDA
IDA: Inferred from direct assay
22423968 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
27321907 MGI
involved in execution phase of necroptosis IMP
IMP: Inferred from mutant phenotype
27746097 MGI
involved in lymph node development IGI
IGI: Inferred from genetic interaction
21876153 MGI
acts upstream of or within necroptotic process IGI
IGI: Inferred from genetic interaction
19498109 MGI
involved in necroptotic process IMP
IMP: Inferred from mutant phenotype
24012422 MGI
acts upstream of or within positive effect non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
25367573 MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
10490590 MGI
acts upstream of or within positive regulation of ligase activity IDA
IDA: Inferred from direct assay
19498109 MGI
involved in positive regulation of necroptotic process IDA
IDA: Inferred from direct assay
22423968 MGI
involved in positive regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
acts upstream of or within positive regulation of oxidoreductase activity IDA
IDA: Inferred from direct assay
19498109 MGI
acts upstream of or within positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
19498109 MGI
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
acts upstream of or within positive regulation of transferase activity IGI
IGI: Inferred from genetic interaction
19498109 MGI
involved in programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
27258785 MGI
acts upstream of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
19498109 MGI
involved in regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation IGI
IGI: Inferred from genetic interaction
21876153 MGI
involved in regulation of T cell mediated cytotoxicity IGI
IGI: Inferred from genetic interaction
21876153 MGI
involved in regulation of activated T cell proliferation IGI
IGI: Inferred from genetic interaction
21876153 MGI
involved in regulation of activation-induced cell death of T cells IGI
IGI: Inferred from genetic interaction
21876153 MGI
involved in regulation of adaptive immune response IGI
IGI: Inferred from genetic interaction
21876153 MGI
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
32200799 MGI
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
27321907 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
involved in regulation of type II interferon production IGI
IGI: Inferred from genetic interaction
21876153 MGI
involved in spleen development IGI
IGI: Inferred from genetic interaction
21876153 MGI
involved in thymus development IGI
IGI: Inferred from genetic interaction
21876153 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28607035 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
10490590 MGI
located in nucleus IDA
IDA: Inferred from direct assay
28607035 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ripk3 Protein Structure

PKc_like

PKc_like: cl21453 (27 - 283)

RHIM

RHIM: pfam12721 (412 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 486 a.a.
Protein Preferred Names Protein Names

receptor-interacting serine/threonine-protein kinase 3

  • RIP-3

  • RIP-like protein kinase 3

  • mRIP3

  • receptor interacting protein 3

Ripk3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ripk3 Q9QZL0 Ripk1 Mus musculus Q60855
Anti Bait CoIP
22922364
Intra
Ripk3 Q9QZL0 Ripk1 Mus musculus Q60855
Anti Bait CoIP
19524513
Intra
Ripk3 Q9QZL0 Mlkl Mus musculus Q9D2Y4
Anti Tag CoIP
22265413
Cross
Ripk3 Q9QZL0 DAXX Homo sapiens Q9UER7
Pull Down
23260419
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Ripk3 Proteins

Cat. No. Product Name Accession Purity
HY-P71853 RIPK3 Protein, Mouse (P.pastoris, His) Q9QZL0 (M1-K486) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101872 GSK-872 Inhibitor 99.91% Unkown
HY-101872A GSK-872 hydrochloride Inhibitor 98.85% Unkown
HY-158312 UH15-38 Inhibitor 99.80% Unkown
HY-104021 GSK840 Inhibitor 99.95% Unkown
HY-125402 GSK-843 Inhibitor 99.53% Unkown
HY-N2909 Aurantiamide Inhibitor 99.56% Unkown
HY-N0546 Ligustroflavone Inhibitor 99.90% Unkown
HY-131064 RIPK3-IN-1 Inhibitor 99.30% Unkown
HY-148365 NecroIr1 Activator 98.53% Unkown
HY-148366 NecroIr2 Activator 98.02% Unkown
HY-151873 SZM679 Inhibitor 99.59% Unkown
HY-183564 RIPK1/RIPK3-PPI-IN-1 Inhibitor / Unkown
HY-180806 RIPK1-IN-39 Inhibitor / Unkown
HY-173454 RIPK2/3-IN-2 Inhibitor 99.67% Unkown
HY-175026 RIPK2-IN-8 Inhibitor / Unkown
HY-171986 RIPK3-IN-6 Inhibitor 98.03% Unkown
HY-181596 WJH-C19 Inhibitor 98.65% Unkown
HY-178163 Zharp1-163 Inhibitor / Unkown
HY-184686 RIPK1-IN-42 Inhibitor / Unkown
HY-183339 IL-6/RIPK3-IN-1 Inhibitor / Unkown
HY-183538 Necroptosis inducer 2 Activator / Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-158312A UH15-38 TFA Inhibitor 99.77% Unkown
HY-184001 LT-1339-553 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ripk3 NCBI NCBI:11035