Mlkl - mixed lineage kinase domain-like Gene

Also Known as 9130019I15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74568

Summary

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced Necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in Necroptosis pathway. Knockout of this gene in mice showed that it is essential for Necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Mlkl Products (2)

mRNA Protein Name
NM_001310613.1 NP_001297542.1 mixed lineage kinase domain-like protein isoform 1
NM_029005.3 NP_083281.1 mixed lineage kinase domain-like protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
24012422 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22265413 MGI
NOT enables protein kinase activity IDA
IDA: Inferred from direct assay
24012422 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
24012422 MGI
Biological Process GO Annotation Evidence References Source
involved in defense response to virus IDA
IDA: Inferred from direct assay
32200799 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
27321907 MGI
involved in execution phase of necroptosis IDA
IDA: Inferred from direct assay
32200799 MGI
involved in execution phase of necroptosis IMP
IMP: Inferred from mutant phenotype
27321907 MGI
involved in necroptotic process IMP
IMP: Inferred from mutant phenotype
23835476 MGI
involved in necroptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
22265413 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
32200799 MGI
located in nucleus IDA
IDA: Inferred from direct assay
32200799 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
32200799 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mixed lineage kinase domain-like protein

Mlkl Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mlkl Q9D2Y4 Ripk3 Mus musculus Q9QZL0
Anti Tag CoIP
26559832
Cross: Cross-species interaction Intra: Intraspecies interaction

Mlkl Antibodies

Cat. No. Product Name Application Reactivity
HY-P80468 Phospho-MLKL (Ser345) Antibody (YA174) WB, IHC-P Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (57)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100573 Necrosulfonamide 98.61% Unkown
HY-10587 BIX-01294 98.44% Unkown
HY-15594A Phen-DC3 Trifluoromethanesulfonate 98.64% Unkown
HY-112292 GW806742X Inhibitor 99.91% Unkown
HY-144828 RIP1/RIP3/MLKL activator 1 97.0% Unkown
HY-101524 TC13172 Inhibitor 99.04% Unkown
HY-162424 ZBP1/RIP3/MLKL activator 1 Activator 99.73% Unkown
HY-N0660 Jujuboside B 99.92% Unkown
HY-156591 PROTAC MLKL Degrader-1 99.76% Unkown
HY-N2909 Aurantiamide Inhibitor 99.56% Unkown
HY-112292A GW806742X hydrochloride Inhibitor 98.30% Unkown
HY-N0546 Ligustroflavone 99.90% Unkown
HY-108239 BIX-01294 trihydrochloride 99.68% Unkown
HY-156119 MLKL-IN-6 Inhibitor 98.57% Unkown
HY-141889 MLKL-IN-2 Inhibitor 99.45% Unkown
HY-157039 RIPK1-IN-17 Inhibitor 97.09% Unkown
HY-149393 RIPK3-IN-3 Inhibitor 95.98% Unkown
HY-100573A (E/Z)-Necrosulfonamide 98.03% Unkown
HY-108636 RETRA 99.42% Unkown
HY-100573S Necrosulfonamide-d4 99.65% Unkown
HY-148365 NecroIr1 98.53% Unkown
HY-148366 NecroIr2 98.02% Unkown
HY-RS08492 MLKL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177119 ZBP1 Covalent PROTAC-1 96.87% Unkown
HY-139878 MLKL-IN-1 Inhibitor / Unkown
HY-148767 MLKL-IN-5 Inhibitor / Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-151541 MLKL-IN-3 Inhibitor / Unkown
HY-161361 MLKL-IN-7 Inhibitor / Unkown
HY-168640 RIP3 activator 1 / Unkown
HY-169072 PROTAC MLKL Degrader-2 / Unkown
HY-169073 TC13172-NH2 Ligand / Unkown
HY-169074 Thalidomide-N-methylpiperazine / Unkown
HY-169509 Topoisomerase I/II inhibitor 8 / Unkown
HY-173075 Anticancer agent 267 / Unkown
HY-173185 RIP1-IN-1 Inhibitor / Unkown
HY-175705 MLKL ligand-1 Ligand / Unkown
HY-176407 ZYH-23 Inhibitor / Unkown
HY-178163 Zharp1-163 Inhibitor / Unkown
HY-178464 RIPK1-IN-34 Inhibitor / Unkown
HY-179680 RIPK1-IN-38 Inhibitor / Unkown
HY-180806 RIPK1-IN-39 Inhibitor / Unkown
HY-181596 WJH-C19 Inhibitor 98.65% Unkown
HY-182066 Photosensitizer-9 Activator / Unkown
HY-182343 PROTAC MLKL Degrader-3 / Unkown
HY-182344 MLKL ligand-2 Ligand / Unkown
HY-183538 Necroptosis inducer 2 / Unkown
HY-183564 RIPK1/RIPK3-PPI-IN-1 Inhibitor / Unkown
HY-183781 RIPK1-IN-41 Inhibitor / Unkown
HY-184686 RIPK1-IN-42 Inhibitor / Unkown
HY-N0660R Jujuboside B (Standard) / Unkown
HY-N20708 Chiisanogenin / Unkown
HY-151542 MLKL-IN-4 Inhibitor / Unkown
HY-N8380 (-)-Latifolin / Unkown
HY-RS16563 Mlkl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22995 Mlkl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15594 Phen-DC3 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mlkl NCBI NCBI:197259