2. PROTAC MAPK/ERK Pathway
  3. Ligands for Target Protein for PROTAC Mixed Lineage Kinase
  4. MLKL ligand-2

MLKL ligand-2 is a mixed lineage kinase domain-like pseudokinase (MLKL) PROTAC ligand with a KD of 9.408 μM. MLKL ligand-2 forms hydrogen bond networks and hydrophobic interactions with specific MLKL residues, and stabilizes MLKL in hepatic cells. MLKL ligand-2 can be used to synthesize PROTAC MLKL Degrader-3 (HY-182343).

For research use only. We do not sell to patients.

MLKL ligand-2

MLKL ligand-2 Chemical Structure

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MLKL ligand-2 Related Antibodies

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Description

MLKL ligand-2 is a mixed lineage kinase domain-like pseudokinase (MLKL) PROTAC ligand with a KD of 9.408 μM. MLKL ligand-2 forms hydrogen bond networks and hydrophobic interactions with specific MLKL residues, and stabilizes MLKL in hepatic cells. MLKL ligand-2 can be used to synthesize PROTAC MLKL Degrader-3 (HY-182343)[1].

In Vitro

MLKL ligand-2 (Compound 5) (1.563-5.000 μM) binds to purified MLKL protein with a KD of 9.408 μM[1].
MLKL ligand-2 (25 μM; 4 h) stabilizes MLKL protein in Hepa1−6 cells, confirming cellular target engagement[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MLKL ligand-2 Related Antibodies

Western Blot Analysis[1]

Cell Line: Hepa1−6 cells
Concentration: 25 μM
Incubation Time: 4 h
Result: Stabilized MLKL protein.
Molecular Weight

658.67

Formula

C30H30F4N8O3S
SMILES

NC1=C(C2=C(C=N1)C3=CN(N=C3)C4CCNCC4)C(C5=CC(OC(C6=CC=C(C=C6)F)C)=C(C=C5F)NS(=O)(C(F)F)=O)=NN2C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MLKL ligand-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MLKL ligand-2MLKL ligand2MLKL ligand 2Ligands for Target Protein for PROTACMixed Lineage KinaseTarget Protein-binding MoietyMLKsMLKLHepa1?6 cellshepatic cellsInhibitorinhibitorinhibit

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