RIP3 activator 1
RIP3 activator 1 (compound C8) is a potent RIP3 activator. RIP3 activator 1 inhibits cell growth. RIP3 activator 1 induces necroptosis through the RIP3/p62/Keap1 signaling pathway. RIP3 activator 1 increases the protein expression of p-MLKL. RIP3 activator 1 induces autophagy. RIP3 activator 1 increases accumulation of LC3-II and p62 protein expression.
For research use only. We do not sell to patients.
- CAS No.: 1456899-52-7
- Formula: C26H50N4O3
- Molecular Weight:466.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| EC9706 | IC50 |
2.29 μM
Compound: 14h
|
Antiproliferative activity against human EC9706 cells after 48 hrs by MTT assay
Antiproliferative activity against human EC9706 cells after 48 hrs by MTT assay
|
[PMID: 24835817] |
| MCF7 | IC50 |
1.93 μM
Compound: 14h
|
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 24835817] |
| MGC-803 | IC50 |
3.11 μM
Compound: 14h
|
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
|
[PMID: 24835817] |
Chemical Information
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CAS No. 1456899-52-7
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Molecular Weight 466.70
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Formula C26H50N4O3
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SMILES
O[C@@H]1[C@@H](N)CO[C@H]1COCC(N=N2)=CN2CCCCCCCCCCCCCCCCCC
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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