2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Phen-DC3

Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Phen-DC3 Trifluoromethanesulfonate) that retains the same biological activity.

For research use only. We do not sell to patients.

Phen-DC3 Chemical Structure

Phen-DC3 Chemical Structure

CAS No. : 942936-75-6

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Other Forms of Phen-DC3:

Phen-DC3 Related Antibodies

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Description

Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.

IC50 & Target

IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)[1].
Molecular Weight

550.61

Formula

C34H26N6O2
CAS No.
SMILES

C[N+]1=C2C=CC=CC2=CC(NC(C3=CC=C4C=CC5=CC=C(C(NC6=C[N+](C)=C7C=CC=CC7=C6)=O)N=C5C4=N3)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (61.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8162 mL 9.0808 mL 18.1617 mL
5 mM 0.3632 mL 1.8162 mL 3.6323 mL
View the Complete Stock Solution Preparation Table

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8162 mL 9.0808 mL 18.1617 mL 45.4042 mL
5 mM 0.3632 mL 1.8162 mL 3.6323 mL 9.0808 mL
10 mM 0.1816 mL 0.9081 mL 1.8162 mL 4.5404 mL
15 mM 0.1211 mL 0.6054 mL 1.2108 mL 3.0269 mL
20 mM 0.0908 mL 0.4540 mL 0.9081 mL 2.2702 mL
25 mM 0.0726 mL 0.3632 mL 0.7265 mL 1.8162 mL
30 mM 0.0605 mL 0.3027 mL 0.6054 mL 1.5135 mL
40 mM 0.0454 mL 0.2270 mL 0.4540 mL 1.1351 mL
50 mM 0.0363 mL 0.1816 mL 0.3632 mL 0.9081 mL
60 mM 0.0303 mL 0.1513 mL 0.3027 mL 0.7567 mL
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Phen-DC3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phen-DC3942936-75-6DNA/RNA SynthesisInhibitorinhibitorinhibit

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