Topoisomerase I/II inhibitor 8
Topoisomerase I/II Inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of Topoisomerase I/II, capable of inducing DNA damage and PARP-1 activation, which subsequently leads to the activation of RIPK1, RIPK3, and MLKL, ultimately triggering necroptosis. Topoisomerase I/II Inhibitor 8 demonstrates remarkable anticancer activity by effectively targeting the nuclei of cancer cells and inducing cell death through necroptosis, showing great clinical potential in circumventing drug resistance in cancer treatment.
For research use only. We do not sell to patients.
- CAS No.: 355400-87-2
- Formula: C14H11Br2NO5S2
- Molecular Weight:497.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
Chemical Information
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CAS No. 355400-87-2
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Molecular Weight 497.18
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Formula C14H11Br2NO5S2
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SMILES
O=C(CN1C(/C(SC1=S)=C/C2=CC(OCC)=C(C(Br)=C2Br)O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topoisomerase I/II inhibitor 8 Related Classifications
HY-169509 Related Classifications
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