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Cat. No.: HY-161361

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MLKL-IN-7

MLKL-IN-7 (compound 9) is a MLKL inhibitor, and shows anti-necroptosis activity in HT-29 cells with the IC₅₀ of 148.4 nM.

For research use only. We do not sell to patients.

CAS No.: 3034839-17-0
Formula: C₂₁H₁₅N₅O₅S₂
Molecular Weight:481.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

MLKL-IN-7 Chemical Structure

CAS No.: 3034839-17-0

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Sample (0.1mg)

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(In Japan)

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

MLKL-IN-7 (compound 9) is a MLKL inhibitor, and shows anti-necroptosis activity in HT-29 cells with the IC₅₀ of 148.4 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	EC₅₀	148.4 nM Compound: 9	Anti-necroptosis activity against TNFalpha/Smac mimetic/Z-VAD-fmk-induced human HT-29 cells by CellTiter luminescence cell viability assay Anti-necroptosis activity against TNFalpha/Smac mimetic/Z-VAD-fmk-induced human HT-29 cells by CellTiter luminescence cell viability assay	[PMID: 38442525]

Chemical Information

CAS No. 3034839-17-0
Molecular Weight 481.50
Formula C₂₁H₁₅N₅O₅S₂
SMILES

O=C(NC1=CC=C(S(=O)(NC2=NC=C3C=CC=CC3=N2)=O)C=C1)/C=C/C4=CC=C([N+]([O-])=O)S4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tang Y, et al. Design, synthesis and anti-necroptosis activity of fused heterocyclic MLKL inhibitors. Bioorg Med Chem. Published online March 1, 2024. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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