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Art. -Nr.: HY-161361

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MLKL-IN-7

MLKL-IN-7 (compound 9) is a MLKL inhibitor, and shows anti-necroptosis activity in HT-29 cells with the IC₅₀ of 148.4 nM.

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CAS. Nr.: 3034839-17-0
Formel: C₂₁H₁₅N₅O₅S₂
Molecular Weight:481.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

MLKL-IN-7 Chemical Structure

CAS. Nr.: 3034839-17-0

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MLKL-IN-7 (compound 9) is a MLKL inhibitor, and shows anti-necroptosis activity in HT-29 cells with the IC₅₀ of 148.4 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	EC₅₀	148.4 nM Compound: 9	Anti-necroptosis activity against TNFalpha/Smac mimetic/Z-VAD-fmk-induced human HT-29 cells by CellTiter luminescence cell viability assay Anti-necroptosis activity against TNFalpha/Smac mimetic/Z-VAD-fmk-induced human HT-29 cells by CellTiter luminescence cell viability assay	[PMID: 38442525]

Chemical Information

CAS. Nr. 3034839-17-0
Molecular Weight 481.50
Formel C₂₁H₁₅N₅O₅S₂
SMILES

O=C(NC1=CC=C(S(=O)(NC2=NC=C3C=CC=CC3=N2)=O)C=C1)/C=C/C4=CC=C([N+]([O-])=O)S4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tang Y, et al. Design, synthesis and anti-necroptosis activity of fused heterocyclic MLKL inhibitors. Bioorg Med Chem. Published online March 1, 2024. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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