MLKL-IN-7
MLKL-IN-7 (compound 9) is a MLKL inhibitor, and shows anti-necroptosis activity in HT-29 cells with the IC50 of 148.4 nM.
For research use only. We do not sell to patients.
- CAS No.: 3034839-17-0
- Formula: C21H15N5O5S2
- Molecular Weight:481.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | EC50 |
148.4 nM
Compound: 9
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Anti-necroptosis activity against TNFalpha/Smac mimetic/Z-VAD-fmk-induced human HT-29 cells by CellTiter luminescence cell viability assay
Anti-necroptosis activity against TNFalpha/Smac mimetic/Z-VAD-fmk-induced human HT-29 cells by CellTiter luminescence cell viability assay
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[PMID: 38442525] |
Chemical Information
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CAS No. 3034839-17-0
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Molecular Weight 481.50
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Formula C21H15N5O5S2
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SMILES
O=C(NC1=CC=C(S(=O)(NC2=NC=C3C=CC=CC3=N2)=O)C=C1)/C=C/C4=CC=C([N+]([O-])=O)S4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MLKL-IN-7 Related Classifications
HY-161361 Related Classifications
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