Ripk1 - receptor (TNFRSF)-interacting serine-threonine kinase 1 Gene

Also Known as RIP; Rinp; Rip1; RIP-1; D330015H01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19766

About Ripk1

Chromosome 13: 34,186,346-34,221,130 forward strand.GRCm39:CM001006.3

This gene has 5 transcripts (splice variants), 198 orthologues, 23 paralogues and is associated with 21 phenotypes. Ubiquitous expression in ovary adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues.

Summary

Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of cardiac muscle cell proliferation; and regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of extrinsic apoptotic signaling pathway; and ripoptosome assembly involved in necroptotic process. Predicted to be located in several cellular components, including cytosol; membrane raft; and mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Is expressed in several structures, including central nervous system; heart; liver; lung; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ripk1 Products (2)

mRNA Protein Name
NM_001359997.1 NP_001346926.1 receptor-interacting serine/threonine-protein kinase 1
NM_009068.3 NP_033094.3 receptor-interacting serine/threonine-protein kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16680093 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
29440439 MGI
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
25015821 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
28701375 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
27819682 MGI
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
18641653 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
21876153 MGI
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
28842570 MGI
involved in cellular response to growth factor stimulus IMP
IMP: Inferred from mutant phenotype
20125124 MGI
involved in cellular response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
27258785 MGI
involved in necroptotic process IDA
IDA: Inferred from direct assay
28701375 MGI
acts upstream of or within necroptotic process IGI
IGI: Inferred from genetic interaction
19498109 MGI
involved in necroptotic process IMP
IMP: Inferred from mutant phenotype
28842570 MGI
involved in necroptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21876153 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
24813849 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
22089168 MGI
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
20125124 MGI
involved in negative regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
24813849 MGI
involved in peptidyl-serine autophosphorylation IMP
IMP: Inferred from mutant phenotype
31827281 MGI
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
20125124 MGI
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
20125124 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
20125124 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
22089168 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
9529147 MGI
involved in positive regulation of execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
26555174 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
19498109 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
31827281 MGI
involved in positive regulation of interleukin-6-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
31827281 MGI
involved in positive regulation of phosphorylation IMP
IMP: Inferred from mutant phenotype
21052097 MGI
acts upstream of or within positive regulation of transferase activity IGI
IGI: Inferred from genetic interaction
19498109 MGI
involved in positive regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
30439713 MGI
involved in programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
27258785 MGI
involved in protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
29440439 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
acts upstream of or within ripoptosome assembly involved in necroptotic process IGI
IGI: Inferred from genetic interaction
21052097 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ripk1 Protein Structure

PKc_like

PKc_like: cl21453 (22 - 290)

Death_RIP1

Death_RIP1: cd08777 (567 - 652)

  • 0
  • 200
  • 400
  • 600
  • 656 a.a.
Protein Preferred Names Protein Names

receptor-interacting serine/threonine-protein kinase 1

  • cell death protein RIP

  • receptor-interacting protein 1

  • serine/threonine-protein kinase RIP

Ripk1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ripk1 Q60855 Tradd Mus musculus Q3U0V2
Anti Tag CoIP
18719121
Intra
Ripk1 Q60855 Ripk3 Mus musculus Q9QZL0
Anti Bait CoIP
19524513
Intra
Ripk1 Q60855 Rps27a Mus musculus P62991
Comigration in SDS
18719121
Intra
Ripk1 Q60855 Tnfrsf1a Mus musculus P25118
Anti Bait CoIP
16680093
Intra
Ripk1 Q60855 Fadd Mus musculus Q61160
Anti Bait CoIP
26555174
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148787 Oditrasertib Inhibitor 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (58)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14622A Necrostatin 2 racemate Inhibitor 99.57% Unkown
HY-134050 Apostatin-1 Inhibitor 99.64% Unkown
HY-138779 ICCB-19 hydrochloride Inhibitor 99.25% Unkown
HY-14622 Necrostatin 2 Inhibitor 99.78% Unkown
HY-114371 Eclitasertib Inhibitor 99.80% Unkown
HY-N0546 Ligustroflavone Inhibitor 99.90% Unkown
HY-124546 Necrostatin-5 Inhibitor 99.40% Unkown
HY-148297 Ocadusertib Inhibitor 99.57% Unkown
HY-153598 LD4172 Degrader 98.32% Unkown
HY-128348 PK68 Inhibitor 99.92% Unkown
HY-18901 RIPK1-IN-4 Inhibitor 98.89% Unkown
HY-161059 ZB-R-55 Inhibitor 99.39% Unkown
HY-161060 Zharp1-211 Inhibitor 99.15% Unkown
HY-152846 Flizasertib Inhibitor 99.9% Unkown
HY-157039 RIPK1-IN-17 Inhibitor 97.09% Unkown
HY-14622B Necrostatin 2 (S enantiomer) Inhibitor 99.76% Unkown
HY-157456 RIPK1-IN-19 Inhibitor 98.87% Unkown
HY-120548 KBU2046 98.85% Unkown
HY-151873 SZM679 Inhibitor 99.59% Unkown
HY-148365 NecroIr1 Activator 98.53% Unkown
HY-149258 KWCN-41 Inhibitor 99.83% Unkown
HY-148366 NecroIr2 Activator 98.02% Unkown
HY-132203 Necrostatin-34 Inhibitor 98.90% Unkown
HY-175370 PROTAC RIPK1 Degrader-1 Degrader 99.66% Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-157963 RIPK1-IN-23 Inhibitor / Unkown
HY-173185 RIP1-IN-1 Inhibitor / Unkown
HY-153437 PB830 Inhibitor / Unkown
HY-170232 RIPK1-IN-29 Inhibitor / Unkown
HY-179323 RIPK1-IN-36 Inhibitor / Unkown
HY-178762S RIPK1-IN-35 Inhibitor / Unkown
HY-179680 RIPK1-IN-38 Inhibitor / Unkown
HY-162237 RIPK1-IN-22 Inhibitor / Unkown
HY-181062 VWK147 Inhibitor / Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-160216 RIPK1-IN-18 Inhibitor / Unkown
HY-179235 RIPK1-IN-37 Inhibitor / Unkown
HY-146758 RIPK1-IN-14 Inhibitor / Unkown
HY-161911 Necroptosis-IN-5 Inhibitor / Unkown
HY-178163 Zharp1-163 Inhibitor / Unkown
HY-169107 RIPK1-IN-25 Inhibitor / Unkown
HY-18899 Nec-3a Inhibitor / Unkown
HY-173574 RIPK1-IN-31 Modulator / Unkown
HY-184001 LT-1339-553 Inhibitor / Unkown
HY-175007 RIPK1-IN-32 Inhibitor / Unkown
HY-144276 RIPK1-IN-11 Inhibitor / Unkown
HY-181596 WJH-C19 Inhibitor 98.65% Unkown
HY-183564 RIPK1/RIPK3-PPI-IN-1 Inhibitor / Unkown
HY-180806 RIPK1-IN-39 Inhibitor / Unkown
HY-P10977 Tat-ASIC1a (1-20) (mouse, rat) Inhibitor / Unkown
HY-W319332 Necrostatin-21 Inhibitor / Unkown
HY-143726 RIPK1-IN-8 Inhibitor / Unkown
HY-178464 RIPK1-IN-34 Inhibitor / Unkown
HY-181944 RIPK1-IN-40 Inhibitor / Unkown
HY-175371 RIPK1-ligand-2 Inhibitor / Unkown
HY-183781 RIPK1-IN-41 Inhibitor / Unkown
HY-153434 RIP1 kinase inhibitor 4 Inhibitor / Unkown
HY-175374 RIPK1 ligand-Linker Conjugate-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ripk1 NCBI NCBI:8737