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TRMT112 - tRNA methyltransferase activator subunit 11-2 Gene

Also Known as TRM112; HSPC152; HSPC170; hTrm112; TRMT11-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51504

About TRMT112

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,316,460-64,318,596 (from NCBI)

This gene has 6 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in adrenal (RPKM 47.8), ovary (RPKM 46.2) and 25 other tissues.

Summary

Enables protein heterodimerization activity and protein methyltransferase activity. Involved in macromolecule methylation and positive regulation of rRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

TRMT112 Products (5)

mRNA	Protein	Name
NM_001286082.2	NP_001273011.1	multifunctional methyltransferase subunit TRM112-like protein isoform 2
NM_001286084.2	NP_001273013.1	multifunctional methyltransferase subunit TRM112-like protein isoform 3
NM_001372071.1	NP_001359000.1	multifunctional methyltransferase subunit TRM112-like protein isoform 1
NM_001372072.1	NP_001359001.1	multifunctional methyltransferase subunit TRM112-like protein isoform 1
NM_016404.3	NP_057488.1	multifunctional methyltransferase subunit TRM112-like protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18539146	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	25851604	GOA
enables protein methyltransferase activity	IDA IDA: Inferred from direct assay	18539146	GOA
enables tRNA methyltransferase activator activity	IDA IDA: Inferred from direct assay	34669960	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in peptidyl-glutamine methylation	IDA IDA: Inferred from direct assay	18539146	GOA
involved in positive regulation of rRNA processing	IMP IMP: Inferred from mutant phenotype	25851604	GOA
involved in rRNA (guanine-N7)-methylation	IMP IMP: Inferred from mutant phenotype	25851604	GOA
involved in rRNA methylation	IDA IDA: Inferred from direct assay	31328227	GOA
involved in tRNA methylation	IMP IMP: Inferred from mutant phenotype	34669960	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	31061526	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	25851604	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	25851604	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	18539146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT112 Protein Structure

Trm112p

0
100
125 a.a.

Protein Preferred Names	Protein Names
multifunctional methyltransferase subunit TRM112-like protein	TRM112-like protein

TRMT112 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRMT112	Q9UI30	BUD23	Homo sapiens	O43709	Pull Down	25851604
Intra	TRMT112	Q9UI30	BUD23	Homo sapiens	O43709	Y2H Array	32296183
Intra	TRMT112	Q9UI30	BUD23	Homo sapiens	O43709	Y2H Prey Pooling	32296183
Intra	TRMT112	Q9UI30	BUD23	Homo sapiens	O43709	Anti Tag CoIP	34948388
Intra	TRMT112	Q9UI30	ALKBH8	Homo sapiens	Q96BT7	Y2H	20123966
Intra	TRMT112	Q9UI30	ALKBH8	Homo sapiens	Q96BT7	Pull Down	20123966
Intra	TRMT112	Q9UI30	ALKBH8	Homo sapiens	Q96BT7	Anti Tag CoIP	34948388
Intra	TRMT112	Q9UI30	METTL5	Homo sapiens	Q9NRN9	Anti Tag CoIP	34948388
Intra	TRMT112	Q9UI30	THUMPD2	Homo sapiens	Q9BTF0	Anti Tag CoIP	34948388
Intra	TRMT112	Q9UI30	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	TRMT112	Q9UI30	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	TRMT112	Q9UI30	TRMT11	Homo sapiens	Q7Z4G4	Anti Tag CoIP	34948388
Intra	TRMT112	Q9UI30	THUMPD3	Homo sapiens	Q9BV44	Y2H Array	32296183
Intra	TRMT112	Q9UI30	THUMPD3	Homo sapiens	Q9BV44	Anti Tag CoIP	34948388
Intra	TRMT112	Q9UI30	THUMPD3	Homo sapiens	Q9BV44	Y2H Prey Pooling	32296183
Intra	TRMT112	Q9UI30	N6AMT1	Homo sapiens	Q9Y5N5	Pull Down	25851604
Intra	TRMT112	Q9UI30	N6AMT1	Homo sapiens	Q9Y5N5	Anti Tag CoIP	34948388

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TRMT112 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71644	TRMT112 Protein, Human (His-SUMO)	Q9UI30-1 (M1-S125)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cardiomyopathy, Familial Restrictive, 1	RCM1 Restrictive Cardiomyopathy 1 Rcm Familial Restrictive Cardiomyopathy 1 Cardiomyopathy, Familial Restrictive 1 Cardiomyopathy, Restrictive, Familial, Type 1 Rcm-1
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-181064	FWG-33B	Activator	/	Unkown
HY-RS15090	TRMT112 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20224	Trmt112 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26731	Trmt112 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRMT112	VGNC	VGNC:101420
Canis familiaris	TRMT112	VGNC	VGNC:47855
Felis catus	TRMT112	VGNC	VGNC:81099
Mus musculus	TRMT112	MGD	MGI:1914924
Rattus norvegicus	TRMT112	RGD	RGD:1309710
Others	TRMT112	NCBI