THUMPD3 - THUMP domain containing 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25917

About THUMPD3

This gene has 10 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 18.1), thyroid (RPKM 8.7) and 25 other tissues.

Summary

Predicted to enable tRNA (guanine) methyltransferase activity. Predicted to be involved in tRNA methylation. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

THUMPD3 Products (2)

mRNA	Protein	Name
NM_001114092.2	NP_001107564.1	tRNA (guanine(6)-N2)-methyltransferase THUMP3
NM_015453.3	NP_056268.2	tRNA (guanine(6)-N2)-methyltransferase THUMP3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables tRNA (guanine(6)-N2)-methyltransferase activity	IMP IMP: Inferred from mutant phenotype	34669960	GOA
enables tRNA (guanine(7)-N2)-methyltransferase activity	IMP IMP: Inferred from mutant phenotype	34669960	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in tRNA methylation	IMP IMP: Inferred from mutant phenotype	34669960	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	34669960	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THUMPD3 Protein Structure

THUMP

UPF0020

0
100
200
300
400
507 a.a.

Protein Preferred Names	Protein Names
tRNA (guanine(6)-N2)-methyltransferase THUMP3 THUMP domain-containing protein 3

Protein Preferred Names

Protein Names

tRNA (guanine(6)-N2)-methyltransferase THUMP3

THUMP domain-containing protein 3

THUMPD3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	THUMPD3	Q9BV44	TRMT112	Homo sapiens	Q9UI30	Anti Tag CoIP	33961781
Intra	THUMPD3	Q9BV44	TRMT112	Homo sapiens	Q9UI30	Anti Tag CoIP	28514442
Intra	THUMPD3	Q9BV44	TRMT112	Homo sapiens	Q9UI30	Validated Y2H	32296183
Intra	THUMPD3	Q9BV44	TRMT112	Homo sapiens	Q9UI30	Anti Tag CoIP	34948388
Intra	THUMPD3	Q9BV44	TRMT112	Homo sapiens	Q9UI30	Confocal	34948388

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cerebellar Angioblastoma	Hemangioblastoma Of Cerebellum Cerebellar Hemangioblastoma
Chromosome 3pter-P25 Deletion Syndrome	3p- Syndrome 3p Deletion Syndrome Distal Monosomy 3p Chromosome 3, Monosomy 3p 3p Partial Monosomy Syndrome Chromosome 3, Deletion 3p Chromosome 3p Deletion Syndrome Del Syndrome Deletion 3p Monosomy 3p Partial Monosomy 3p Distal 3p Deletion Monosomy 3pter Telomeric Monosomy 3p Chromosome Deletion Syndrome 3pter-P25

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14510	THUMPD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	THUMPD3	VGNC	VGNC:35855
Rattus norvegicus	THUMPD3	RGD	RGD:1560852
Macaca mulatta	THUMPD3	VGNC	VGNC:79435
Mus musculus	THUMPD3	MGD	MGI:1277973
Felis catus	THUMPD3	VGNC	VGNC:66180